摘要
应用多普勒超声心动图和心导管同步血流动力学研究的方法对３０例左室舒张功能不全的患者观察了静注维拉帕米前后心导管左室松弛性指标和多普勒左室充盈性指标的变化。结果显示所有患者中用药后左室充盈指标显著改善（Ｐ＜０．０５～＜０．００１），但左室松弛性指标仅在心肌肥厚患者中显著改善（Ｐ＜０．０５～＜０．００１），而在心肌梗塞患者中无明显变化，左室充盈与左室松弛指标间无显著相关，提示维拉帕术主要通过降低左室后负荷改善左室充盈，而对于不同病因所致的左室松弛异常则具有不同的影响。
o assess the effects of verapamil on left ventricular relaxation and filling dynamics in patients withleft ventricular diastolic dysfunction(LVDD ), Doppler echocardiography ( DE)and cardiac catheterization(Cath ) were simuItaneously performed in 30 cases with LVDD. The left ventricular filling and relaxationindices were measured with DE and Cath respectively,before and after intravenous injection of verapamil. The result showed that after verapamil injection all left ventricular filling indices measured with DE weresignificantly improved in all cases, while left ventricular relaxation indices showed significant improvementonly in patients with hypertrophic cardiomyopathy and hypertensive heart disease but no changes in pa-tients with old myocardial infarction. There were no significant correlations between left ventricular fillingand relaxation indices.It is concluded that the major mechanism of left ventricular filling improvement in-duced by verapamil is the reduction of left ventrtcular afterload and verapamil has different therapeutic ef-fects on LVDD with different etiology.
出处
《中华内科杂志》
CAS
CSCD
北大核心
1995年第6期378-380,共3页
Chinese Journal of Internal Medicine
