摘要
目的探讨食管癌术后局部复发的放射治疗方法。方法食管癌术后局部复发76例,其中锁骨上区复发24例,纵隔复发34例,锁骨上区加纵隔复发10例,纵隔加吻合口复发8例。全组均行放射治疗,剂量50～70Gy,36例放疗后行DF方案化疗3周期。结果全组中位生存时间12个月,1、2、3年生存率分别为51.3%、26.3%和11.8%。放射治疗后化疗与未行化疗者,3年生存率分别为22.2%和5.0%,P>0.05。多因素分析术后分期(P<0.05)及近期放射治疗效果(P<0.05)与预后密切相关。结论食管癌术后局部复发放射治疗是首选治疗方法,放疗后局部控制好预后也好。放射治疗剂量应以60Gy以上为宜。
Objective To analyze the optimum method of radiotherapy for loco-regional recurrence after surgery for esophageal carcinoma . Methods 76 patients were treated by radiotherapy.24patients had recurrent lesions in the supraclavicular region, 34 in the mediastinum, 10 in both mediastinum plus supraclavicular area and 8 in mediastinum plus anastomotic orifice. A total dose of 50-70Gy was given. 36patients received DF (DDP+Fu) chemotherapy after radiotherapy for 3 cycles. Results The medium survival was 12 months and the 1、2 and 3-year survival rates were 51.3%, 26.3% and 11.8% .For those who received R+C and R only, the 3-year survival rates were 22.2% and 5.0%,P>0.05.Analysis of postoperation stage (P<0.05) and recent radiotherapy effect (P<0.05) was closely related with prognosis. Conclusion Among the various method of treating loco-regional recurrence after surgery of esophageal carcinoma, commonly yielding poor results, radiotherapy is still the method of choice .A total dose of >60Gy is able to effect a good loco-regional control as well as a good result.
出处
《医药论坛杂志》
2005年第4期45-47,共3页
Journal of Medical Forum
关键词
食管癌
肿瘤复发
局部
放射疗法
预后
Esophageal Neoplasm
Neoplasm recurrence
Local
Radiotherapy
Prognosis
