摘要
柏子仁在采收、晾晒、脱皮、风选、运输、储存过程中均易滋生黄曲霉菌,并产生黄曲霉毒素。这严重影响了柏子仁的质量,有致癌、致畸、致突变等危害,柏子仁中黄曲霉毒素污染的问题亟待解决。为加强柏子仁等油性中药的规范化贮藏管理,本文对黄曲霉毒素B_(1)的检测及脱毒方法进行综述。发现检测方法中应用免疫传感器具有检测速度快、灵敏度较高、特异性强、自动化等优势。脱毒技术中采用生物脱毒法更为高效环保,利用不产毒菌发酵液的降解作用,能有效去除累积的真菌毒素;天然植物挥发油对黄曲霉菌的生长及黄曲霉毒素B1的合成也有抑制作用。
Aspergillus flavus is easy to grow and produce toxin in the process of harvesting,drying,peeling,wind sorting,transportation,and storage of Semen platycladi.This not only seriously affects the quality of Semen platycladi,but also causes carcinogenic,teratogenic,and mutagenic effects.Therefore,there is an urgent need to solve the problem of Aspergillus flavus pollution.In order to strengthen the standardized storage management of oily traditional Chinese medicines such as Semen platycladi,this paper reviews the detection and detoxification methods for aflatoxin B1,and proposes that the application of immunosensors has the advantages of fast detection,high sensitivity,high specificity,and automation.The biological detoxification method is more efficient and environmentally friendly,and the degradation of the fermentation broth without toxins can effectively remove the accumulated mycotoxins.Natural plant volatile oils also have an inhibitory effect on the growth of Aspergillus flavus and the synthesis of aflatoxin B1.
作者
李颖
程莹莹
史启今
高琛
杨辉
金敏
Li Ying;Cheng Yingying;Shi Qijin;Gao Chen;Yang Hui;Jin Min(Department of Pharmacy,Guang'anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China)
出处
《中华临床医师杂志（电子版）》
CAS
北大核心
2023年第12期1223-1227,共5页
Chinese Journal of Clinicians(Electronic Edition)
基金
国家中医药管理局2022中医药科学技术研究专项(GZY-KJS-2022-004)
中国中医科学院科技创新工程(CI2022E027XB01)
关键词
柏子仁
黄曲霉菌
黄曲霉毒素B_(1)
检测
脱毒
Semen Platycladi
Aspergillus flavus
Aflatoxin B_(1)
Detection
Detoxification
作者简介
通信作者:金敏,Email:jinmin1208@sina.com
