摘要
目的观察伊班膦酸联合复方苦参注射液治疗恶性肿瘤骨转移癌骨痛的有效性和安全性。方法选取2012年6月~2013年12月于我院肿瘤科治疗的70例恶性肿瘤骨转移患者,其中38例为治疗组接受伊班膦酸联合复方苦参注射液治疗,32例为对照组给予伊班膦酸钠单药治疗。治疗组给予伊班膦酸4 mg加入0.9%氯化钠注射液500 mL,静脉滴注120 min,复方苦参注射液20 mL加入0.9%氯化钠注射液250 mL静脉滴注,d1~14,每4 w重复1次;对照组单用伊班膦酸,方法同治疗组。观察8 w内患者骨痛及体力改善情况。结果治疗组38例患者中有34例骨痛得到了不同程度的缓解,其中20例显效,14例有效,4例无效,有效率为89.5%;对照组32例患者中15例显效,11例有效,6例无效,有效率为81.2%;治疗组有效率高于对照组(<0.05),差异有统计学意义。结论伊班膦酸联合复方苦参注射液对恶性肿瘤骨转移癌引起的骨痛具有良好的治疗作用,毒副反应较轻微。
Objective To evaluate the curative ef icacy and safety of ibandronate Combined with Compound Kushen Injection for treating ostealgia in patients with malignant tumor and osseous metastases.Methods Between Jun.2012 and Dec-2013,70 patients with malignant tumor and osseous metastases were enrol ed in our study,of whom,38 were assigned to trial group treated with compound Kushen injection(20 mL)that was added to 250 mL 0.9%sodium chloride injection by ivgt for two weeks combined with ibandronate acid(4 mg)that was added to 100 mL 0.9%sodium chloride injection by ivgtt within 15 min(this therapy was repeated in every 4 weeks)and 32 to receive ibandronate acid alone which was administered at the same dosage and administration as in the trial group(control group).Ostealgia degree and physical strength improvement were observed within treatment of eight weeks.Results The overal response rate was 89.5%in the trial group(34 showed improvement,with 20 showing excellent response,14 response and 4 no response)vs.81.2%(15 showed excellent response,11 response and 6 no response)in the control group(<0.05).Conclusion Ibandronate Combined with Compound Kushen Injection showed goof efficacy yet mild toxicity for ostealgia in cancer patients with osseous metastases.
作者
袁亚江
高蔚然
YUAN Ya-jiang;GAO Wei-ran(The First Affiliated Hospital of Liaoning Medical University,Jinzhou 121001,Liaoning,China)
关键词
伊班膦酸
复方苦参注射液
骨转移癌
骨痛
Ibandronate
Compound Kushen injection
Ostealgia
Osseous metastasis
作者简介
通讯作者:高蔚然,1983年女,30岁,硕士,主治医师,辽宁医学院附属第一医院肿瘤科,从事肿瘤内科方面治疗5年。
