摘要
目的探讨复方制剂保留灌肠治疗慢性放射性直肠炎(CRP)合并溃疡患者的疗效,并分析影响疗效的因素.方法回顾性分析2012年11月至2018年6月中山大学附属第六医院收治的51例CRP合并溃疡的患者的临床资料,并进行复方制剂保留灌肠疗效的影响因素分析,再进一步比较复方制剂保留灌肠时间不同的患者的治疗有效率.结果51例CRP合并溃疡患者中,18例复方制剂保留灌肠治疗有效,有效率为35.3%.与治疗无效的患者比较,治疗有效的患者中维持复方制剂保留灌肠治疗时间≥6个月者更多(10/18比2/33,P=0.000),毛细血管扩张评分更高[3(1.5,3)比2(0,3),P=0.048],血小板计数更低[(210.3±73.7)×109/L比(252.9±64.8)×109/L,P=0.001],白细胞计数更低[4.7(3.7,5.8)×109/L比6.0(4.6,6.5)×109/L,P=0.027].多因素分析结果显示复方制剂保留灌肠维持治疗时间是疗效的独立影响因素(OR=0.074,95%CI:0.011-0.515),P=0.009).复方制剂保留灌肠维持治疗>6个月的患者的有效率显著高于维持治疗≤3个月组(83.3%比17.8%,P=0.000)和维持治疗>3个月且≤6个月组患者(83.3%比27.3%,P=0.022).结论复方制剂保留灌肠对治疗CRP合并溃疡患者有一定疗效,当复方制剂保留灌肠维持治疗时间超过6个月以上,疗效更显著.
Objective To evaluate the efficacy of retention enema with compound on chronic radiation proctitis(CRP)with rectal ulcer and to analyze its influencing factors.Methods A retrospective study was conducted to analyze the clinical data of 51 patients with ulcerative CRP in the Sixth Affiliated Hospital of Sun Yat-sen University from November 2011 to June 2018.The influencing factors of retention enema with compound were analyzed.And the therapeutic efficiency with different treatment time of it was compared.Results Among the 51 CRP patients with rectal ulcer,there were 18 patients treated effectively by retention enema with compound,and the effective rate was 35.3%.Compared with the patients ineffectively treated,there were more patients maintain treatment by retention enema with compound for more than 6 months among the patients effectively treated(10/18 vs.2/33,P=0.000).And we also found higher telangiectasia scores[3(1.5,3)vs.2(0,3),P=0.048],lower platelet levels[(210.3±73.7)×109/L vs.(252.9±64.8)×109/L),P=0.001]and lower leukocyte levels[4.7(3.7,5.8)×109/L vs.6.0(4.6,6.5)×109/L]in the patients effectively treated.Multivariate analysis revealed that treatment time of retention enema was an independent influencing factor(OR=0.074,95%CI:0.011-0.515,P=0.009).When treated by retention enema with compound on CRP with rectal ulcer,the effective rate of>6 months treatment was significant higher than that of≤3 months treatment(83.3%vs.17.8%,P=0.000)and>3~≤6 months treatment(83.3%vs.27.3%,P=0.022).Conclusion Retention enema with compound had a certain effect on patients with ulcerative CRP.And as the treatment time of retention enema with compound extended to more than 6 months,its efficacy was much more significant.
作者
马腾辉
黄小艳
钟清华
刘占振
邝颖仪
王磊
Ma Tenghui;Huang Xiaoyan;Zhong Qinghua;Liu Zhanzhen;Kuang Yingyi;Wang Lei(Department of Colorectal Surgery,The Sixth Affiliated Hospital,Sun Yat-sen University,Guangzhou 510655,China;Guangdong Institute of Gastroenterology,The Sixth Affiliated Hospital,Sun Yat-sen University,Guangzhou 510655,China)
出处
《中华炎性肠病杂志(中英文)》
2019年第1期68-72,共5页
Chinese Journal of Inflammatory Bowel Diseases
基金
国家自然科学基金(81573078).
关键词
慢性放射性直肠炎
溃疡
保留灌肠
Chronic radiation proctitis
Ulcer
Retention enema
作者简介
通信作者:王磊,Email:wall919@mail.sysu.edu.cn,电话:020-38254052;共同第一作者:马腾辉;共同第一作者:黄小艳
