摘要
目的探讨阿司匹林联合氯吡格雷治疗脑梗死的临床效果.方法选取2021年4月—2022年1月我院收治的86例脑梗死患者为研究对象,按随机数字表法分为两组,各43例.对照组给予阿司匹林治疗,观察组在对照组基础上加用氯吡格雷治疗,持续用药2周.对比两组临床疗效、血液流变学指标、炎症因子水平、神经功能、认知功能、日常生活活动能力及不良反应发生情况.结果观察组治疗总有效率为97.67%,高于对照组的81.40%,差异有统计学意义(P<0.05).治疗2周后,观察组全血高切黏度(4.84±0.63)mpa·s、血浆黏度(1.40±0.27)mpa·s、全血低切黏度(8.01±1.25)mpa·s、C反应蛋白水平(7.35±0.72)mg/L、肿瘤坏死因子-α水平(129.75±15.63)pg/mL、美国国立卫生研究院卒中量表评分(9.87±1.10)分均低于对照组的(6.05±0.77)mpa·s、(1.80±0.32)mpa·s、(9.32±1.07)mpa·s、(9.43±1.40)mg/L、(156.58±16.99)pg/mL、(11.26±1.35)分,简易精神状态量表评分(26.30±0.55)分、日常生活活动能力改良Bathel指数量表评分(75.59±4.60)分均高于对照组的(24.94±1.30)分、(66.70±5.22)分,组间差异有统计学意义(P<0.05).两组不良反应发生率相比,差异无统计学意义(P>0.05).结论阿司匹林联合氯吡格雷能够增强脑梗死治疗效果,减轻神经功能损伤,改善血液流变学指标及炎症因子水平,并促进认知功能及日常生活活动能力恢复,且不良反应少,安全性高.
Objective To investigate the clinical effect of aspirin combined with clopidogrel in the treatment of cerebral infarction.Methods A total of 86 patients with cerebral infarction admitted to our hospital from April 2021 to January 2022 were selected as the research objects,and divided into two groups according to the random number table method,with 43 cases in each group.The control group was treated with aspirin,and the observation group was additionally treated with clopidogrel on the basis of the control group,with both interventions for 2 weeks.The clinical efficacy,hemorheology indexes,inflammatory factor levels,neurological function,cognitive function,activities of daily living and the occurrence of adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was 97.67%,which was higher than 81.40%in the control group,with statistically significant difference(P<0.05).After 2 weeks of treatment,whole blood high cut viscosity(4.84±0.63)mpa·s,plasma viscosity(1.40±0.27)mpa·s,whole blood low shear viscosity(8.01±1.25)mpa·s,C-reactive protein level(7.35±0.72)mg/L,tumor necrosis factor-αlevel(129.75±15.63)pg/mL,National Institutes of Health stroke scale score(9.87±1.10)points in the observation group were lower than(6.05±0.77)mpa·s,(1.80±0.32)mpa·s,(9.32±1.07)mpa·s,(9.43±1.40)mg/L,(156.58±16.99)pg/mL,(11.26±1.35)points in the control group,mini mental state examination score(26.30±0.55)points and Bathel index score(75.59±4.60)points were higher than(24.94±1.30)points,(66.70±5.22)points in the control group,and the differences between the groups were statistically significant(P<0.05).There was no statistical difference in incidence of adverse reactions between the two groups(P>0.05).Conclusion Aspirin combined with clopidogrel can enhance the therapeutic effect of cerebral infarction,reduce neurological damage,improve hemorheological indexes and inflammatory factor levels,and promote the recovery of cognitive function and activities of daily living,with few adverse reactions and high safety.
作者
黑君华
李红娟
HEI Junhua;LI Hongjuan(Department of Neurology,Jiaozhou Hospital,Dongfang Hospital Affiliated to Tongji University,Jiaozhou Shandong,266300,China;Department of Geriatrics,Jiaozhou Hospital,Dongfang Hospital Affiliated to Tongji University,Jiaozhou Shandong,266300,China)
出处
《反射疗法与康复医学》
2022年第13期80-83,共4页
Reflexology And Rehabilitation Medicine
关键词
脑梗死
阿司匹林
氯吡格雷
临床疗效
认知功能
日常生活活动能力
Cerebral infarction
Aspirin
Clopidogrel
Clinical efficacy
Cognitive function
Activities of daily living
作者简介
黑君华(1978-),女,山东胶州人,本科,主治医师,研究方向:脑血管病,邮箱:wutong9136@163.com。
