摘要
目的评估小柴胡汤加味联合三联疗法应用于幽门螺杆菌(Hp)阳性慢性胃炎(CG)患者中的效果.方法选取巨野县中医院2021年6月—2022年7月收治的84例Hp阳性CG患者为研究对象,采用随机数字表法将其分为对照组及观察组,每组42例.对照组采用三联疗法治疗,观察组在此基础上采用小柴胡汤加味治疗.比较两组患者的治疗效果、血清胃肠激素水平、症状缓解时间及Hp根除率.结果观察组的治疗总有效率为95.24%,高于对照组的80.95%,差异有统计学意义(P<0.05).治疗后,观察组的胃蛋白酶原-Ⅱ、胃蛋白酶原-Ⅰ、胃泌素-17水平均低于对照组,组间差异有统计学意义(P<0.05);观察组的泛酸、嗳气、嘈杂、脘腹胀痛等症状缓解时间均短于对照组,组间差异有统计学意义(P<0.05).治疗后,观察组的Hp根除率为92.86%,高于对照组的76.19%,差异有统计学意义(P<0.05).结论Hp阳性CG患者采用小柴胡汤加味联合三联疗法治疗,可缩短症状缓解时间,提高整体疗效及Hp根除率,降低血清胃肠激素水平,值得临床推广使用.
Objective To evaluate the effect of modified Xiaochaihu Decoction combined with triple therapy on Helicobacter pylori(Hp)positive chronic gastritis(CG).Methods 84 HP-positive CG patients admitted to Juye County Traditional Chinese Medicine Hospital from June 2021 to July 2022 were selected as the study objects and were divided into a control group and an observation group by random number table method,with 42 cases in each group.The control group was treated with triple therapy,and the observation group was treated with modified Xiaochaihu Decoction on this basis.The therapeutic effect,serum gastrointestinal hormone levels,symptom remission time and Hp eradication rate were compared between the two groups.Results The total effective rate of observation group was 95.24%,higher than 80.95%of control group,the difference was statistically significant(P<0.05).After treatment,the levels of pepsinogenⅡ,pepsinogenⅠand gastrin-17 in the observation group were lower than those in the control group,the differences between the groups were statistically significant(P<0.05);the remission time of pantothenic acid,belching,noisy and abdominal distension pain in the observation group were shorter than those in the control group,and the differences between the groups were statistically significant(P<0.05);the Hp eradication rate in the observation group was 92.86%,higher than 76.19%in the control group,and the difference was statistically significant(P<0.05).Conclusion The treatment of HP-positive CG patients with modified Xiaochaihu Decoction combined with triple therapy can shorten the time of symptom remission,improve the overall curative effect and Hp eradication rate,and reduce the levels of serum gastrointestinal hormone,which is worthy of clinical popularization.
作者
侯凯
HOU Kai(Department of Preventive Medicine,Juye County Traditional Chinese Medicine Hospital,Heze City,Shandong Province,Heze Shandong,274900,China)
出处
《反射疗法与康复医学》
2023年第16期38-40,44,共4页
Reflexology And Rehabilitation Medicine
关键词
慢性胃炎
HP阳性
小柴胡汤加味
三联疗法
症状缓解时间
血清胃肠激素
Chronic gastritis
Hp positive
Modified Xiaochaihu Decoction
Triple therapy
Symptom remission time
Serum gastrointestinal hormone
作者简介
侯凯(1989-),男,山东菏泽人,硕士研究生,主治医师,研究方向:经方在脾胃病治疗中的应用。