摘要
目的分析消痞汤联合隔姜灸治疗对乳腺癌化疗后胃肠道反应的影响.方法选择该院2021年1月—2023年1月收治的85例乳腺癌化疗患者为研究对象,按电脑随机数字表法将其分为对照组和观察组.对照组(n=42)采用隔姜灸治疗,观察组(n=43)在对照组基础上联用消痞汤治疗,比较两组治疗前后的临床疗效、中医证候积分、血清因子、胃肠激素、胃肠道反应.结果观察组治疗总有效率为95.35%,高于对照组的80.95%,差异有统计学意义(P<0.05).治疗开始前1d,两组腹胀腹痛、恶心反酸、便溏纳差症状比较,组间差异无统计学意义(P>0.05).治疗结束后1d,观察组腹胀腹痛、恶心反酸、便溏纳差症状积分分别为(1.11±0.04)分、(2.31±0.26)分、(1.93±0.08)分,均低于对照组的(2.32±0.09)分、(3.09±0.34)分、(2.31±0.10)分,组间差异有统计学意义(P<0.05).治疗开始前1d,两组降钙素基因相关肽(CGRP)和胃促生长素、5-羟色胺(5-HT)水平比较,组间差异无统计学意义(P>0.05).治疗结束后1d,观察组CGRP和胃促生长素、5-HT水平分别为(92.31±2.05)pg/mL、(70.60±10.23)ng/mL、(279.71±52.17)ng/mL,均高于对照组的(83.01±2.10)pg/mL、(61.25±8.29)ng/mL、(235.38±41.11)ng/mL,组间差异有统计学意义(P<0.05).观察组胃肠道不良反应发生率为11.63%,低于对照组的30.95%,差异有统计学意义(P<0.05).结论消痞汤联合隔姜灸治疗有助于调节乳腺癌化疗后患者的胃肠因子,减轻其胃肠道不良反应,治疗安全性和实用性较高.
Objective To analyze the effect of Xiaopi Decoction combined with ginger separated moxibustion on gastrointestinal reaction after chemotherapy for breast cancer.Methods Eighty five patients with breast cancer treated with chemotherapy in this hospital from January 2021 to January 2023 were selected as the research objects,divided into a control group and an observation group using a computer random number table method.The control group(n=42)was treated with ginger separated moxibustion,while the observation group(n=43)was treated with Xiaopi decoction on the basis of the control group.The clinical efficacy,TCM syndrome scores,serum factors and gastrointestinal hormones,and gastrointestinal reactions of the two groups were compared before and after treatment.Results The total effective rate of the observation group was 95.35%,which was higher than 80.95%of the control group,the difference was statistically significant(P<0.05).One day before the start of treatment,there were no statistically significant differences in the symptoms of abdominal distension,abdominal pain,nausea,acid reflux,and loose stools between the two groups(P>0.05).One day after the end of treatment,the symptom scores of abdominal distension,abdominal pain,nausea,acid reflux,and loose stools in the observation group were(1.11±0.04)points,(2.31±0.26)points,and(1.93±0.08)points,respectively,lower than the control group's(2.32±0.09)points,(3.09±0.34)points,and(2.31±0.10)points,the differences between the groups were statistically significant(P<0.05).One day before the start of treatment,there were no statistically significant differences in the levels of calcitonin gene related peptide(CGRP),ghrelin,and 5-hydroxytryptamine(5-HT)between the two groups(P>0.05).One day after the end of treatment,the levels of CGRP,ghrelin,and 5-HT in the observation group were(92.31±2.05)pg/mL,(70.60±10.23)ng/mL,and(279.71±52.17)ng/mL,respectively,higher than(83.01±2.10)pg/mL,(61.25±8.29)ng/mL,and(235.38±41.11)ng/mL in the control group,the differences between groups were statistically significant(P<0.05).The incidence of gastrointestinal adverse reactions in the observation group was 11.63%,lower than the control group's 30.95%,the difference was statistically significant(P<0.05).Conclusion Xiaopi decoction combined with ginger separated moxibustion is helpful to regulate gastrointestinal factors in patients with breast cancer after chemotherapy,reduce their gastrointestinal adverse reactions,and is safe and practical.
作者
张兰红
孙丽艳
ZHANG Lanhong;SUN Liyan(Department of Oncology,Zibo Infectious Disease Hospital,Zibo Shandong,255000,China)
出处
《反射疗法与康复医学》
2024年第2期38-41,共4页
Reflexology And Rehabilitation Medicine
关键词
乳腺癌
消痞汤
隔姜灸
胃肠道反应
胃肠因子
Breast cancer
Xiaopi decoction
Ginger separated moxibustion
Gastrointestinal reactions
Gastrointestinal factors
作者简介
张兰红(1987-),女,山东淄博人,硕士研究生,主治医师,研究方向:肿瘤诊治。
