摘要
In the issue of Gastroenterology published October 2018,the article by Moon et al.1 demonstrated that screening patients with cirrhosis for hepatocellular carcinoma(HCC)by ultrasound scan(USS),measurement of serumα-fetoprotein(AFP),each alone or in combination,was not associated with the decreased HCC-related mortality.In this matched case control study,all the study patients were registered in detail in the U.S.Department of Veterans Affairs.The study included 238 cases who died of HCC with cirrhosis,and the same number of matched controls with cirrhosis who had been enrolled in U.S.Department of Veterans Affairs care for the 4 years before the index date and alive at the time of their matched case's death.The study retrospectively collected each case's USS and AFP screening data for 4 years before the date of HCC diagnosis or the equivalent index date in controls.Authors found that there was no significant difference of frequency of routine screening between the cases and controls.Therefore,the authors interpreted these results as indicating that the routine screening would not reduce cancer-related mortality.
基金
the National S&T Major Project for Infectious Diseases(No.20177X10201201)
作者简介
Correspondence to:Fengmin Lu,Department of Microbiology&Infectious Disease Center,School of Basic Medical Sciences,Peking University Health Science Center,38 Xueyuan Rd,Haidian District,Beijing 100191,China.Tel:+86-10-82805136,Fax:+86-10-82805136,E-mail:lu.fengmin@hsc.pku.edu.cn;Correspondence to:Chunfeng Qu,State Key Laboratory of Molecular Oncology,National Cancer Center/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,17 Pan-jia-yuan South Lane,Chaoyang District,Beijing 100021,China.Tel:+86-10-87783103,Fax:+86-10-67713917,E-mail:quchf@cicams.ac.cn
