摘要
目的探讨甲泼尼龙辅助治疗子宫内膜异位症(endometriosis,EMT)合并反复早期自然流产(recurrent earlyspontaneous abortion,ERSA)的效果及对血管内皮生长因子(vascular endothelial growth factor,VEGF)分泌型受体可溶性类FMS酪氨酸激酶(soluble FMS-like tyrosine kinase-1,sFlt)-1、VEGF及C反应蛋白(C reactive protein,CRP)的影响。方法选择2019年6月至2020年6月于商丘市民权县中医院妇产科接受治疗的EMT合并ERSA患者85例,采用随机数表法分为观察组(n=43)和对照组(n=42)。对照组给予促性腺激素释放激素激动剂,观察组在对照组治疗基础上加用甲泼尼龙辅助治疗。比较两组临床疗效、血清s Flt-1、VEGF、CRP、雌二醇(estradiol,E2)、孕酮(progesterone,P)、卵泡刺激素(folliclestimulating hormone,FSH)、促黄体生成素(luteinizing hormone,LH)、白介素(interleukin,IL)-6、肿瘤坏死因子(tumor necrosis factor,TNF)-α、D-二聚体(D-dimer,D-D)、凝血酶原时间(prothrombin time,PT)、活化部分凝血活酶时间(activated partial thromboplastin time,APTT)水平及不良反应发生情况。结果治疗后,观察组总有效率高于对照组(95.35%vs 69.05%),差异有统计学意义(P<0.05)。两组血清sFlt-1、D-D水平均较治疗前升高,且观察组高于对照组,VEGF、E2、P、FSH、LH、IL-6、TNF-α、CRP、PT、APTT水平均较治疗前降低,且观察组低于对照组(P<0.05)。结论在EMT合并ERSA患者中应用甲泼尼龙辅助治疗,效果显著,可能与其可有效改善sFlt-1、VEGF及CRP水平相关。
Objective To explore the effect of methylprednisolone in the adjuvant treatment of endometriosis(EMT)combined with early recurrent spontaneous abortion(ERSA)and its effects on levels of soluble FMS-like tyrosine kinase(sFlt)-1,vascular endothelial growth factor(VEGF)and C reactive protein(CRP).Methods A total of 85 patients with EMT complicated with ERSA treated in department of obstetrics and gynecology,Minquan county hospital of traditional Chinese medicine from June 2019 to June 2020 were selected and divided into observation group(n=43)and control group(n=42)by random number table method.The control group was given gonadotropin-releasing hormone agonist,and the observation group was given methylprednisolone adjuvant therapy on the basis of the control group.Clinical efficacy,serum sFlt-1,VEGF,CRP,estradiol(E2),progesterone(P),and follicle-stimulating hormone(FSH),luteinizing hormone(LH),interleukin(IL)-6,tumor necrosis factor(TNF)-α,D-dimer(D-D),prothrombin time(PT),activated partial thromboplastin time(APTT)levels and the incidence of adverse reactions were compared between the two groups.Results After treatment,the total effective rate of observation group was higher than that of control group(95.35%vs 69.05%),and the difference was statistically significant(P<0.05).Serum sFlt-1 and D-D in both groups were higher than before treatment,and the observation group was higher than the control group(P<0.05).The levels of VEGF,E2,P,FSH,LH,IL-6,TNF-α,CRP,PT and APTT in both groups were lower than before treatment,and the observation group was lower than the control group(P<0.05).Conclusion Methylprednisolone adjuvant therapy has a significant effect in EMT patients complicated with ERSA,which may be related to the effective improvement of sFlt-1,VEGF and CRP levels.
作者
何顺昱
杨栋霞
HE Shunyu;YANG Dongxia(Department of Obstetrics and Gynecology,Minquan County Hospital of Traditional Chinese Medicine,Shangqiu 476800,Henan Province,China;Department of Obstetrics and Gynecology,Zhengzhou First People's Hospital,Zhengzhou 450004,Henan Province,China)
出处
《世界临床药物》
CAS
2022年第12期1586-1591,共6页
World Clinical Drug
作者简介
何顺昱,主治医师,研究方向:妇产科临床。
