摘要
目的观察针刺对急性盆腔炎(APID)患者免疫功能和炎症状态的影响。方法选取2018年3月—2019年3月医院收治的50例APID患者,随机分为观察组和对照组,各25例。对照组采用常规西药治疗(左氧氟沙星、甲硝唑静脉滴注),观察组联合中医针刺治疗,7 d为1个疗程,治疗2个疗程。比较两组临床症状改善时间、住院时间、中医证候积分及治疗前后的免疫功能指标、血清炎症因子[白细胞介素1β(IL-1β)、C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、降钙素原(PCT)]、血常规检查[白细胞计数(WBC)、中性粒细胞计数(NEU),魏氏法检测血沉(ESR)]的变化,根据妇科超声检查情况比较两组包块大小及盆腔积液深度,记录治疗期间不良反应发生率及随访3个月的复发率。结果观察组疗效总有效率显著高于对照组(P<0.05);观察组临床症状改善时间及住院时间显著短于对照组(P<0.05);治疗后观察组中医证候积分均显著低于对照组,IL-1β、CRP、TNF-α、PCT水平均显著低于对照组(P<0.05);治疗后观察组CD^(+)_(3)、CD^(+)_(4)、CD^(+)_(4)/CD^(+)_(8)显著高于对照组,CD^(+)_(8)水平显著低于对照组(P<0.05);治疗后观察组WBC、NEU、ESR及包块大小、盆腔积液深度显著小于对照组(P<0.05);两组不良反应发生率比较差异无统计学意义(P>0.05);观察组复发率显著低于对照组(P<0.05)。结论针刺治疗可明显提高APID患者免疫功能,调节血清炎症因子表达,改善其临床症状。
Objective To observe the effects of acupuncture on immune function and inflammatory state in patients with acute pelvic inflammatory disease(APID).Methods A total of 50 patients with APID who were admitted to the hospital between March 2018 and March 2019 were selected as the subjects.They were randomly divided into the observation group and the control group with 25 cases in each group.The control group was treated with conventional western medicine(intravenous infusion of levofloxacin and metronidazole).On the basis,the observation group was additionally treated with acupuncture.Seven days was a course of treatment,and they were given 2 courses of treatment.The clinical symptom improvement time,hospitalization time,TCM symptom scores,changes in serum inflammatory factors[interleukin-1β(IL-1β),C-reactive protein(CRP),tumor necrosis factor-α(TNF-α),procalcitonin(PCT)]and blood routine[white blood cell count(WBC),neutrophil count(NEU)]and erythrocyte sedimentation rate(ESR)detected by Westergren method before and after treatment were compared between the two groups.According to the results of gynecological ultrasound examination,the size of the mass and the depth of pelvic fluid were compared between the two groups.The incidence of adverse reactions during treatment and the recurrence rate in 3 months of follow-up were recorded.Results The total response rate of the observation group was significantly higher than that of the control group(P<0.05).The clinical symptom improvement time and hospitalization time of the observation group were significantly shorter than those of the control group(P<0.05).After treatment,TCM syndrome scores of the observation group were significantly lower than those of the control group.The levels of IL-1β,CRP,TNF-αand PCT were significantly lower than those in the control group(P<0.05).After treatment,CD^(+)_(3),CD^(+)_(4)and CD^(+)_(4)/CD^(+)_(8)in the observation group were significantly higher than those in the control group,while CD^(+)_(8)was significantly lower than that of the control group(P<0.05).WBC,NEU,ESR,the size of the mass and the depth of pelvic fluid in the observation group after treatment were significantly smaller than those in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).The recurrence rate of the observation group was significantly lower than that of the control group(P<0.05).Conclusion Acupuncture treatment can significantly improve the immune function of patients with APID,regulate the expressions of serum inflammatory factors,and improve the clinical symptoms.
作者
卢洪丹
李凌涛
金远林
LU Hongdan;LI Lingtao;JIN Yuanlin(Baoan District Hospital of Traditional Chinese Medicine,Guangzhou University of Chinese Medicine,Shenzhen 518000,Guangdong,China)
出处
《辽宁中医杂志》
CAS
2022年第6期177-180,共4页
Liaoning Journal of Traditional Chinese Medicine
基金
广东省医学科学技术研究基金(B2009151)
关键词
针刺
急性盆腔炎
免疫功能
炎症状态
acupuncture
acute pelvic inflammatory disease
immune function
inflammatory state
作者简介
卢洪丹(1990-),女,广东梅州人,主治医师,学士,研究方向:针灸临床治疗学;通讯作者:金远林(1963-),男,湖北人,主任医师,学士,研究方向:针灸临床治疗学。
