摘要
目的探讨疏肝和胃汤联合四联疗法对肝胃不和型胃溃疡患者的临床疗效并观察其对血清炎症因子的影响。方法选取2019年5月至2020年10月就诊于辽宁中医药大学附属医院的胃溃疡(肝胃不和型)患者96例,利用随机数字表法随机分为单纯西医治疗组和中西医结合治疗组,每组48例,单纯西医治疗组应用四联疗法治疗,中西医结合治疗组在单纯西医治疗组基础之上服用疏肝和胃汤,比较两组治疗后临床治疗有效率,治疗前后中医症状积分、炎症因子水平、胃肠激素水平和治疗后不良反应发生情况。结果中西医结合治疗组治疗后临床总有效率高于单纯西医治疗组,两组治疗后胃脘胀痛、纳差、善太息、心烦等症状评分均低于同组治疗前且中西医结合治疗组降低更明显,两组治疗后C反应蛋白(C-reactionprotein,CRP)、肿瘤坏死因子α(tumor necrosis factor-α,TNF-α)和白介素6(interleukin-6,IL-6)等炎症因子水平均低于同组治疗前且中西医结合治疗组降低更明显,两组治疗后胃泌素(gastrin,GAS)水平均低于同组治疗前且中西医结合治疗组降低更明显,两组治疗后生长抑素(somatostatin,SS)水平均高于同组治疗前且中西医结合治疗组升高更明显,中西医结合治疗组治疗后不良反应发生率低于单纯西医治疗组。结论疏肝和胃汤联合四联疗法治疗肝胃不和型胃溃疡临床有效,可明显减轻临床症状,对炎症因子和胃肠激素水平具有一定的控制作用,且服用安全可靠,值得临床推广应用。
Objective To explore the clinical efficacy of Shugan Hewei Decoction(疏肝和胃汤)combined with quadruple therapy on patients with gastric ulcer with discordant liver and stomach and observe its effect on serum inflammatory factors.Methods Ninety-six patients with gastric ulcer(hepato-gastric discord)who were treated in the affiliated hospital of Liaoning university of traditional Chinese medicine from May 2019 to October 2020 were selected and randomly divided into a simple Western medicine treatment group and an integrated traditional Chinese and Western medicine treatment group using a random number table method,48 cases in each group,the simple Western medicine treatment group was treated with quadruple therapy,and the integrated traditional Chinese and Western medicine treatment group took Shugan Hewei Decoction on the basis of the simple Western medicine treatment group.The clinical treatment efficiency of the two groups after treatment was compared,and the TCM syndrome before and after treatment syndrome score,inflammatory factor levels,gastrointestinal hormone levels and adverse reactions after treatment.Results The total clinical effective rate after treatment in the integrated traditional Chinese and Western medicine treatment group was higher than that in the Western-only treatment group.After treatment,the scores of symptoms such as gastric pain,anorexia,santai,and upset in the two groups were lower than those in the same group before treatment and the integrated traditional Chinese and Western medicine treatment group.The reduction was more obvious.After treatment,the levels of CRP,TNF-α,IL-6 and other inflammatory factors in the two groups were lower than those in the same group before treatment,and the reduction was more obvious in the integrated traditional Chinese and Western medicine treatment group.After treatment,the GAS levels in the two groups were lower than those in the same group.The former and the integrated traditional Chinese and Western medicine treatment group decreased more significantly.The SS levels of the two groups after treatment were higher than those of the same group before treatment.The increase was more obvious in the integrated traditional Chinese and Western medicine treatment group.The incidence of adverse reactions in the integrated traditional Chinese and Western medicine treatment group was lower than that of Western medicine alone.therapy group.Conclusion Shugan Hewei Decoction combined with quadruple therapy is clinically effective in treating gastric ulcer with discordant liver and stomach,can significantly reduce clinical symptoms,have a certain control effect on inflammatory factors and gastrointestinal hormone levels,and is safe and reliable to take,and is worthy of clinical application.
作者
赵丽君
张世超
ZHAO Lijun;ZHANG Shichao(Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110032,Liaoning,China)
出处
《辽宁中医药大学学报》
CAS
2021年第9期178-181,共4页
Journal of Liaoning University of Traditional Chinese Medicine
基金
国家“十二五”科技支撑计划项目(2014BAI10B00)
关键词
疏肝和胃汤
四联疗法
胃溃疡
临床疗效
炎症因子
Shugan Hewei Decoction(疏肝和胃汤)
quadruple therapy
stomach ulcer
clinical efficacy
inflammatory factors
作者简介
赵丽君(1963-),女,辽宁沈阳人,副主任护师,学士,研究方向:内科疾病的临床研究。
