摘要
【目的】探讨塞来昔布超前镇痛在股骨骨折术后镇痛中的作用及效果。【方法】股骨骨折切开复位内固定术患者72例,随机分为两组,观察组和对照组,每组36例。观察组使用塞来昔布超前镇痛方案,对照组使用常规镇痛,观察两组患者术后2、6、12、24、48 h的视觉疼痛模拟评分(visual analogue scale,VAS);6 h时的舒适评分(brugrmann comfort scale,BCS);48 h内患者自控静脉镇痛泵(analgesia patient self-controlled,PCIA)有效按压次数;72 h内药物不良反应发生情况、睡眠质量评分(pittsburgh sleep quality index,PSQI)、术后疼痛控制有效率和护理满意度等。【结果】术后各时间点观察组患者的VAS评分均显著低于对照组(P<0.05);6 h时观察组的BCS评分明显高于对照组(P<0.05);观察组在术后48 h内患者PCIA有效次数以及镇痛泵用药量都小于对照组(P<0.05);术后72 h内,观察组患者药物不良反应发生率是13.89%,对照组是38.89%,差异有统计学意义(P<0.05);观察组PSQI评分显著高于对照组(P<0.05);观察组患者的术后疼痛控制有效率是88.56%,对照组是61.11%,差异有统计学意义(P<0.05);观察组患者的术后护理满意度是86.11%,对照组是58.33%,差异有统计学意义(P<0.05)。【结论】塞来昔布超前镇痛可有效缓解股骨骨折患者术后的疼痛、减轻患者的身心不适、提高患者住院期间睡眠质量与就医体验、降低术后镇痛药物的使用量和患者药物不良反应发生率。
【Objective】To explore the role and efficacy of celecoxib in preemptive analgesia of postoperative femoral fractures.【Methods】A total of 72 patients with femoral fracture undergoing open reduction and internal fixation were randomly divided into 2 groups,observation group and control group,36 cases per group.The patients in the observation group were treated with celecoxib for preemptive analgesia,while those in the control group were treated with routine analgesia.The visual pain simulation scores(VAS)were observed at 2 h,6 h,12 h,24 h,and 48 h after surgery.Time comfort score(BCS)at 6 h,effective compression times of patientcontrolled intravenous analgesia pump(PICA)within 48 h,occurrence of adverse drug reactions within 72 h,sleep quality score(PSQI),postoperative pain control efficiency and nursing satisfaction,etc were recorded.【Results】The VAS score in the observation group was significantly lower than that in the control group at each time point after surgery(P<0.05).The BCS score in the observation group was significantly higher than that in the control group at 6 h(P<0.05).The effective times of patient-controlled intravenous analgesia pump(PCIA)and dosage of analgesic pump in the observation group were less than those in the control group within 48 h after surgery(P<0.05).Within 72 h after surgery,the incidence of adverse drug reactions was 13.89%in the observation group and 38.89%in the control group.The difference between the two groups was statistically significant(P<0.05).The PSQI score in the observation group was significantly higher than that in the control group(P<0.05).The effective rate of postoperative pain control was 88.56%in the observation group and 61.11%in the control group.There was statistically significant difference between the two groups(P<0.05).The postoperative care satisfaction was 86.11%in the observation group and58.33%in the control group.The difference between the two groups was statistically significant(P<0.05).【Conclusion】Celecoxib for preemptive analgesia can effectively relieve postoperative pain in patients with femoral fractures,reduce physical and mental discomfort,improve sleep quality and medical experience during hospitalization,and reduce the use of postoperative analgesics as well as the adverse drug reactions rate.
作者
李军
王晶
许立
张立明
康剑锋
孙明林
刘志军
LI Jun;WANG Jing;XU Li;ZHANG Li-ming;KANG Jian-feng;SUN Ming-lin;LIU Zhi-jun(Department of the 3rd Surgical,Hebei Corps Hospital of PAP,Shijiazhuang 050000,China)
出处
《武警后勤学院学报（医学版）》
CAS
2020年第5期6-9,共4页
Journal of Logistics University of PAP（Medical Sciences）
基金
国家自然科学基金资助重点项目(11432016)
国家自然科学基金资助面上项目(31370942)
关键词
超前镇痛
股骨骨折
塞来昔布
术后疼痛
Preemptive analgesia
Femoral fracture
Celecoxib
Postoperative pain
作者简介
李军,硕士,医师,主要从事脊柱损伤和脊柱外科手术工作;通信作者:刘志军,硕士,副主任医师,主要从事普外科疾病的微创治疗工作,E-mail:465628296@qq.com。
