摘要
目的探讨晚期肺癌炎症指数(ALI)对晚期胃癌患者一线化疗后预后的影响。方法回顾性分析2016年1月-2020年12月在河北省人民医院确诊为晚期胃癌的134例患者的临床资料。计算ALI,通过受试者工作特征(ROC)曲线确定ALI的最佳截断值,根据截断值分为高、低两组,分析两组与临床病理特征、疾病控制率(DCR)和预后的关系。结果化疗前ALI最佳截断值为399.35,高ALI与肿瘤TNM分期、部位、远处转移灶数目和中性粒细胞/淋巴细胞比值(NLR)显著相关(χ^(2)=7.480、6.888、12.086、78.323,P均<0.05)。高ALI组DCR显著高于低ALI组,差异有统计学意义(χ^(2)=4.889,P<0.05)。在预测生存能力方面,高ALI组与低ALI组的中位总生存期分别为23个月和13个月,差异有统计学意义(P<0.05)。Cox回归分析显示远处转移灶数目(HR=0.543,95%CI:0.304~0.969)和ALI(HR=0.322,95%CI:0.122~0.849)是影响晚期胃癌患者总生存期的独立预后因素,差异有统计学意义(P<0.05)。结论ALI水平可作为晚期胃癌患者化疗后的预后指标,化疗前低ALI水平是预后的独立危险因素。
Objective To investigate the effect of advanced lung cancer inflammation index(ALI)on the prognosis of advanced gastric cancer patients after first-line chemotherapy.Methods The clinical data of 134 patients with confirmed advanced gastric cancer attending the Hebei General Hospital from January 2016 to December 2020 were retrospectively analyzed.The optimal cut-off value of ALI was determined by the receiver operating characteristic(ROC)curve,and the two groups were divided into high and low groups according to the cut-off value,and the relationship between the two groups and clinicopathological characteristics,disease control rate(DCR)and prognosis was analyzed.Results The optimal cutoff value of ALI before chemotherapy was 399.35,and high ALI was significantly correlated with TNM stage,location,number of distant metastases and neutrophil-to-lymphocyte ratio(NLR)(χ^(2)=7.480,6.888,12.086,78.323;all P<0.05).The DCR in the high ALI group was significantly higher than that in the low ALI group,and the difference was statistically significant(χ^(2)=4.889,P<0.05).In terms of predicting viability,the median overall survival was 23 months and 13 months in the high ALI group versus the low ALI group,respectively,and the difference was statistically significant(P<0.05).Cox regression analysis showed that the number of distant metastases(HR=0.543,95%CI:0.304-0.969)and ALI(HR=0.322,95%CI:0.122-0.849)were independent prognostic factors for overall survival in patients with advanced gastric cancer,and the differences were statistically significant(P<0.05).Conclusion ALI level could be used as a prognostic indicator for patients with advanced gastric cancer after chemotherapy,and low ALI level before chemotherapy was an independent risk factor for prognosis.
作者
任燕燕
彭丽丽
刘贤明
王发艳
张洪珍
REN Yanyan;PENG Lili;LIU Xianming;WANG Fayan;ZHANG Hongzhen(Graduate School of Hebei North University,Zhangjiakou,Hebei 075000,China;Department of Oncology,Hebei General Hospital,Shijiazhuang,Hebei 050000,China)
出处
《热带医学杂志》
CAS
2023年第11期1582-1587,共6页
Journal of Tropical Medicine
基金
河北省中医药管理局科研计划(2018075)
关键词
晚期肺癌炎症指数
胃癌
化疗
Advanced lung cancer inflammation index
Gastric cancer
Chemotherapy
作者简介
任燕燕(1996-),女,在读硕士研究生,医师,主要从事恶性肿瘤临床研究;通信作者:张洪珍,E-mail:hongzhenzhang456@sohu.com
