摘要
2型糖尿病(Type 2 diabetes mellitus,T2DM)是一种以胰岛素和葡萄糖失调为特征的慢性代谢性疾病,作为一种与日常饮食密切相关的疾病,其发病分子机制尚不清楚。甜味觉受体是一类7次跨膜的G蛋白偶联受体,虽然对T2DM发病机理的研究逐渐深入,但是目前疾病状态下甜味觉损伤机制研究较少,因此,深入研究T2DM甜味觉受体损伤病理机制,对了解甜味觉受体分子特征、探索中医药治疗T2DM新靶点均具有重要意义。在此,本文就甜味觉受体的生物学特征、甜味觉受体的信号传导机制、甜味觉受体与T2DM、甜味觉受体与“脾在味为甘”等方面进行综述,旨在为T2DM的中医药针对性防治及相关病理机理的阐明提供最新的见解,为下一步设计新的具有良好效果的甜味觉受体激动剂提供参考。
Type 2 Diabetes Mellitus(T2DM)is a chronic metabolic disease characterized by disorders of insulin and glucose.As a disease closely related to our daily diet,the molecular mechanism of its pathogenesis is still unclear.Sweet taste receptors are a kind of G protein-coupled receptors with 7 times transmembrane.Although the research on the pathogenesis of T2DM has been gradually deepened,there are few studies on the mechanism of sweet taste damage in the state of disease.Therefore,in-depth study of the pathological mechanism of T2DM sweet taste receptor damage is of great significance to further understand the molecular characteristics of sweet taste receptors and explore new targets of traditional Chinese medicine in the treatment of T2DM.In this paper,the biological characteristics of sweet taste receptors,signal transduction mechanism of sweet taste receptors,sweet taste receptors and T2DM,sweet taste receptors and"spleen is sweet"are reviewed in order to provide the latest opinions for the targeted prevention and treatment of this kind of diseases by traditional Chinese medicine and the elucidation of related pathological mechanism.
作者
孙铁锋
战丽彬
臧凝子
杭天怡
朱连连
Sun Tiefeng;Zhan Libin;Zang Ningzi;Hang Tianyi;Zhu Lianlian(School of Traditional Chinese Medicine&School of Integrated Traditional Chinese and Western Medicine,Modern Research Laboratory of Spleen Visceral Manifestations Theory,Nanjing University of Chinese Medicine,Nanjing 210023,China;the Innovation Engineering Technology Center of Chinese Medicine,Liaoning University of Traditional Chinese Medicine,Shenyang 110847,China;Key Laboratory of Ministry of Education for TCM Viscera-State Theory and Applications,Ministry of Education of China,Liaoning University of Traditional Chinese Medicine,Shenyang 110847,China;the First Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110032,China)
出处
《世界科学技术-中医药现代化》
CSCD
北大核心
2023年第8期2660-2667,共8页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
国家自然科学基金委员会面上项目(82274377):从“脾在味为甘”理论探究参苓白术撒调控“肠道菌群-肠道糖异生-甜味觉受体”干预肥胖T2DM机制(82274377),负责人:战丽彬
国家中医药领军人才岐黄学者支持项目(国中医药人教函[2022]6号),负责人:战丽彬。
关键词
甜味觉受体
2型糖尿病
脾在味为甘
研究进展
Sweet taste receptor
Type 2 diabetes mellutis
Spleen is sweet
Research progress
作者简介
通讯作者:战丽彬,本刊编委,教授,博士生导师,主要研究方向:脾脏象理论及应用的基础与临床研究。
