摘要
目的探讨血清糖原蛋白50(CA50)、巨噬细胞抑制因子1(MIC-1)、胸苷激酶1(TK1)水平与结直肠癌病情的关系,以期为临床早期诊断、评估病情提供依据。方法选取2019-08-05-2021-08-05周口市中心医院收治的128例结直肠癌患者作为观察组,另选取同院同期64名健康体检者作为对照组。入院后均进行血清学相关指标检测,比较2组间及不同临床分期、有无淋巴结转移患者血清CA50、MIC-1、TK1水平,logistic回归方程分析上述指标与结直肠癌临床分期关系,受试者工作特征曲线(ROC)及ROC下面积(AUC)分析血清CA50、MIC-1、TK1水平对结直肠癌的诊断价值。结果对照组血清CA50、MIC-1、TK1水平分别为9.58IU/mL、424.73ng/L、1.25pmol/L,观察组分别为72.48IU/mL、966.28ng/L、3.38pmol/L,观察组高于对照组,均P<0.05。T_(4)期患者CA50、MIC-1、TK1水平分别为85.54IU/mL、1173.27ng/L、4.15pmol/L,T_(3)期分别为68.32IU/mL、895.34ng/L、3.17pmol/L,T_(1)~T_(2)期分别为59.67IU/mL、770.89ng/L、2.57pmol/L,T_(4)期>T_(3)期>T_(1)~T_(2)期,均P<0.05。N_(2)期患者血清CA50、MIC-1、TK1水平分别为87.37 IU/mL、1241.25ng/L、4.28pmol/L,N_(1)期分别为73.15IU/mL、917.53ng/L、3.45pmol/L,N_(0)期分别为65.26IU/mL、765.63ng/L、3.03pmol/L,N_(2)期>N_(1)期>N_(0)期,均P<0.05。logistic回归方程分析结果显示,血清CA50、MIC-1、TK1水平与结直肠癌临床分期呈正相关,OR(95%CI)分别为11.079(5.252~23.373)、12.886(6.259~26.528)、9.681(4.963~18.884),均P<0.001。血清CA50、MIC-1、TK1水平对结直肠癌诊断AUC分别为0.832、0.873、0.806,联合诊断AUC为0.926,大于任一单一指标诊断。结论血清CA50、MIC-1、TK1对于结直肠癌具有较高诊断价值,临床可通过联合检测进行早期筛查及恶性程度评估,为制定相应治疗方案提供可靠依据。
Objective To investigate the relationship between the levels of serum glycogen protein 50(CA50),macrophage inhibitory cytokine-1(MIC-1),thymidine kinase 1(TK1)and colorectal cancer,in order to provide a reference for early clinical diagnosis and assessment of the disease.Methods A total of 128 patients with colorectal cancer who were treated in Zhoukou Central Hospital from August 5,2019 to August 5,2021 were selected as the research group,and 64 healthy people who underwent physical examination during the same period were selected as the control group.After admission,serological related indicators were detected.The levels of serum CA50,MIC-1 and TK1 in patients with different clinical stages and with or without lymph node metastasis in two groups were compared.Logistic regression equation was used to analyze the relationship between the above indicators and clinical stages of colorectal cancer.Receiver operating characteristic curve(ROC)and the area under ROC(AUC)were used to analyze the diagnostic value of serum CA50,MIC-1 and TK1 levels for colorectal cancer.Results The serum CA50,MIC-1,TK1 levels were(9.58 IU/ml,424.73 ng/L,1.25 pmol/L)in the control group at admission,and(72.48 IU/ml,966.28 ng/L,3.38 pmol/L)in the study group,which was higher than those in the control group(P<0.05);CA50,MIC-1,TK1 levels were 85.54 IU/ml,1173.27 ng/L,4.15 pmol/L at T_(4)stage,respectively;68.32 IU/ml,895.34 ng/L,3.17 pmol/L at T_(3)stage,respectively and 59.67 IU/ml,770.89 ng/L,2.57 pmol/L at T_(1)-T_(2)stage,respectively.T_(4)>T_(3)>T_(1)-T_(2)(P<0.05).Serum CA50,MIC-1,TK1 levels in patients at N_(2)stage at admission were 87.37 IU/ml,1241.25 ng/L,4.28 pmol/L;those at N_(1)stage were 73.15IU/ml,917.53ng/L,3.45pmol/L and those at N_(0)stage were 65.26IU/ml,765.63ng/L,3.03pmol/L.N_(2)>N_(1)>N_(0)(P<0.05).Logistic regression equation analysis showed that serum CA50,MIC-1,TK1levels at admission were positively correlated with clinical stage of colorectal cancer[OR(95%CI):11.079(5.252-23.373),12.886(6.259-26.528),9.681(4.963-18.884),P<0.001];The AUC of serum CA50,MIC-1,TK1levels for the diagnosis of colorectal cancer were 0.832,0.873and 0.806,respectively,and the AUC of the combined diagnosis was 0.926,which was greater than the diagnosis of any single index.Conclusions Serum CA50,MIC-1and TK1have high value in the diagnosis of colorectal cancer.Combined detection can be used for early screening and diagnosis and evaluation of malignancy,which provides a reliable basis for formulating corresponding treatment plans.
作者
卢东方
张新丽
武娟
杨柯
LU Dong-fang;ZHANG Xin-li;WU Juan;YANG Ke(Department of Laboratory Medicine,Zhoukou Central Hospital,Zhoukou 466000,China)
出处
《社区医学杂志》
CAS
2022年第23期1332-1336,共5页
Journal Of Community Medicine
关键词
结直肠癌
糖原蛋白
抑制因子
胸苷激酶
诊断
colorectal cancer
glycogen protein
inhibitor
thymidine kinase
diagnosis
作者简介
通信作者:卢东方,男,河南周口人,主管检验师,主要从事医学检验相关的临床研究工作。E-mail:guyt658@163.com
