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玻璃酸钠关节腔注射联合骨痛灵酊治疗膝骨关节炎患者的临床对照研究

Sodium hyaluronate intra-articular injection combined with bone pain tincture in the treatment of knee osteoarthritis
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摘要 目的观察膝骨关节炎患者行骨痛灵酊联合玻璃酸钠关节腔注射治疗的效果。方法选取2023年5月—2024年1月延安市中医医院收治的80例膝骨关节炎患者作为研究对象,以不同的治疗方式分为联合组和单药组,各40例。单药组患者实施玻璃酸钠注射液治疗,联合组在单药组的基础上增加骨痛灵酊湿敷治疗。对比两组的治疗效果、膝关节功能、关节运动状态、症状积分和不良反应发生率。结果两组的治疗效果比较,联合组的疗效更佳(χ^(2)=8.538,P<0.05)。联合组患者的奎森疼痛指数(Lequesne)评分、西安大略和麦克马斯特大学骨关节炎指数(Western Ontario and McMaster Universities arthritis index,WOMAC)均比单药组患者低,Lysholm评分比单药组高(P<0.05)。经治疗,两组患者的症状积分均降低,但与单药组相比,联合组的症状积分更低(P<0.05)。两组的不良反应发生率比较,差异有统计学意义(χ^(2)=7.314,P<0.05)。结论骨痛灵酊与玻璃酸钠注射能有效改善膝骨关节炎患者关节肿胀、疼痛和晨僵等相关症状,避免关节损伤,促进患者膝关节功能恢复。 Objective To observe the effect of intra-articular injection of osteoarthritis combined with sodium hyaluronate in patients with knee osteoarthritis.Methods A total of 80 patients with knee osteoarthritis admitted to Yan'an Hospital of Traditional Chinese Medicine from May 2023 to January 2024 were selected as the study subjects,and 40 patients were treated in combination group and monotherapy group with different treatment methods.Patients in the monotherapy group were treated with sodium hyaluronate injection,and in the combination group,the tincture of bone pain was added to the monotherapy group.The treatment effect,knee function,joint movement status,symptom score and incidence of adverse reactions were compared between the two groups.Results The treatment effect of the two groups was comparable,and the effect was better in the combination group(χ^(2)=8.538,P<0.05).The Lequesne score and Western Ontario and McMaster Universities arthritis index(WOMAC)were lower than those in the single agent group,and the Lysholm score was higher than that in the single agent group(P<0.05).After treatment,the symptom scores of the patients in both groups were reduced,but the symptom scores were lower in the combination group compared with the monotherapy group(P<0.05).The incidence of adverse reactions was compared between the two groups,the difference was statistically significant(χ^(2)=7.314,P<0.05).Conclusion Bone pain tincture and sodium hyaluronate injection can effectively improve the symptoms of joint swelling,pain and morning stiffness in patients with knee osteoarthritis,avoid joint damage,and promote the recovery of knee joint function.
作者 刘瑞 LIU Rui(Department of Orthopedics,Yan'an Hospital of Traditional Chinese Medicine(Yan'an Branch of the Third Hospital of Beijing Medical University),Yan'an,Shanxi 716000,China)
出处 《慢性病学杂志》 2024年第8期1146-1149,共4页 Chronic Pathematology Journal
关键词 膝骨关节炎 骨痛灵酊 玻璃酸钠 关节腔 症状积分 Knee osteoarthritis Tincture of bone pain Sodium hyaluronate Joint cavity Symptom points
作者简介 通信作者:刘瑞,硕士研究生,副主任医师,研究方向:骨关节疾病的研究及中西医结合治疗,E-mail:747435022@qq.com
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