摘要
目的研究分析盐酸西那卡塞联合骨化三醇冲击治疗难治性继发性甲旁亢的临床疗效。方法选择2018年4月至2020年4月我院肾内科血液透析中心收治的30例难治性继发性甲旁亢患者作为本次研究主体,根据随机分配的方式将这30例患者分为两组,对照组(15例)接受骨化三醇冲击治疗,观察组(15例)接受盐酸西那卡塞+骨化三醇冲击治疗,对两种治疗方法的疗效进行分析。结果观察组治疗效果优于对照组,有统计学差异(P<0.05);观察组各项指标情况优于对照组,有统计学差异(P<0.05);两组治疗不良反应发生率无统计学差异(P>0.05)。结论联用骨化三醇冲击和盐酸西那卡塞治疗难治性继发性甲旁亢的疗效确切,能显著降低甲状旁腺激素,且安全性较高,值得应用。
Objective To investigate the clinical effect of cinacacet hydrochloride combined with calcitriol in the treatment of refractory secondary hyperparathyroidism.Methods From April 2018 to April 2020,30 patients with refractory secondary hyperparathyroidism in the hemodialysis center of Department of Nephrology of our hospital were selected as the main body of this study.According to the random distribution,these 30 patients were divided into two groups.The control group(15 cases)received calcitriol impact treatment,and the observation group(15 cases)received cinacacet hydrochloride+calcitriol pulse therapy,The curative effect of the two methods was analyzed.Results The treatment effect of the observation group was better than that of the control group,with statistical difference(P<0.05).The indexes of the observation group were better than those of the control group,with statistical difference(P<0.05).The incidence of adverse reactions between the two groups had no statistical difference(P>0.05).Conclusion Combined use of calcitriol shock and cinacacet hydrochloride in the treatment of refractory secondary hyperparathyroidism is effective,can significantly reduce parathyroid hormone,and has high safety,which is worthy of application.
作者
王艳艳
WANG Yan-yan(Central Hospital of Heilongjiang Agricultural Reclamation Hongxinglong Administration Bureau,Shuangyashan,Heilongjiang 155811)
出处
《智慧健康》
2021年第7期106-108,共3页
Smart Healthcare
关键词
盐酸西那卡塞
骨化三醇
难治性继发性甲旁亢
临床疗效
Cinacacet hydrochloride
Calcitriol
Refractory secondary hyperparathyroidism
Clinical effect
