摘要
目的探究分析胺碘酮治疗急性心肌梗死伴心房颤动的临床效果及药理机制。方法本文研究将收治时间在2019年1月-2020年1月的急性心肌梗死伴心房颤动患者作为主要对象,一共选取70例,随机分为两组,观察组35例以及对照组35例,所有患者在入院后均进行常规对症治疗,再采用计算机随机抽签方式,观察组实施胺碘酮治疗,对照组采取常规治疗,分析两组患者治疗后的各项结果。结果观察组患者在临床治疗中表现出总有效例数为34,占比97.14%,对照组患者在临床治疗中表现出总有效例数为29,占比82.86%,临床治疗效果组间对比具有统计学差异(χ^(2)=3.9683,P=0.0463);在用药过程中,观察组患者发生不良反应发生率2.86%低于对照组20.00%(χ^(2)=5.0806,P=0.0241);观察组患者的LVEF、LVEDD、LVESD与对照组LVEF、LVEDD、LVESD指标具有显著差异(P<0.05);观察组心率(71.89±10.36)次/min、P-R间期(149.12±22.51)ms、OTC(419.12±30.41)ms指标和对照组心率(79.81±15.21)次/min、P-R间期(142.86±15.31)ms、OTC(402.17±17.36)ms指标具有差异(P<0.05);观察组住院时间(16.27±1.21)d和症状改善时间(6.12±1.26)d与对照组住院时间(19.11±1.37)d和症状改善时间(9.11±1.21)d比较,具有显著差异(P<0.05)。结论以胺碘酮治疗急性心肌梗死伴心房颤动疗效确切,安全性佳,建议使用。
Objective To explore clinical effect and pharmacological mechanism of amiodarone in treatment of acute myocardial infarction with atrial fibrillation.Methods The study chose 70 patients with acute myocardial infarction and atrial fibrillation from January 2019 to January 2020 as main subjects,and divided them into two groups randomly with computer random lottery,observation group(35 cases)and control group(35 cases).All cases received routine symptomatic treatment after admission.Observation group was treated with amiodarone treatment,and control group with routine treatment,results were analyzed between two groups after treatment.Results Total number of effective cases in clinical treatment of observation group was 34,accounting for 97.14%,and total number of effective cases in clinical treatment of control group was 29,accounting for 82.86%.There was statistical difference between clinical treatment effect groups(χ^(2)=3.9683,P=0.0463);During medication course,adverse reactions in observation group(2.86%)were lower than control group(20.00%)(χ^(2)=5.0806,P=0.0241);LVEF,LVEDd and LVESD in observation group was significantly different from control group(P<0.05);heart rate(71.89±10.36)beats/min,P-R interval(149.12±22.51)ms,OTC(419.12±30.41)ms in observation group was different from control group(79.81±15.21)beats/min,P-R interval(142.86±15.31)ms,OTC(402.17±17.36)MS(P<0.05);length of stay(16.27±1.21)d and symptom improvement time(6.12±1.26)d in observation group was significantly different from control group(19.11±1.37)d and symptom improvement time(9.11±1.21)d(P<0.05).Conclusion Amiodarone is effective and safe in treatment of acute myocardial infarction with atrial fibrillation.
作者
邓云静
DENG Yunjing(Vein Allocation Center,Lanling County People's Hospital,Linyi,Shandong,277700)
出处
《智慧健康》
2022年第27期111-115,共5页
Smart Healthcare
关键词
胺碘酮
急性心肌梗死
心房颤动
临床效果
药理机制
Amiodarone
Acute myocardial infarction
Atrial fibrillation
Clinical effect
Pharmacological mechanism
作者简介
邓云静(1982-),女,汉族,山东临沂,本科,主管药师,研究方向:药学。
