摘要
目的探讨儿童社区获得性肺炎(CAP)血清单核细胞与淋巴细胞比值(MLR)、血小板与淋巴细胞比值(PLR)与疾病严重程度的相关性及危险因素分析。方法选取2021年12月至2022年12月期间北京市大兴区人民医院收治的157例儿童CAP患者作为研究对象,设为疾病组。按照病情的严重程度分为轻症组(n=119)和重症组(n=38)。同时选取体检健康儿童60例作为健康组。比较疾病组和健康组、轻症组和重症组相关指标,并采用Logistic二元回归相关分析对影响因素进行分析。结果疾病组和健康组的性别、年龄、ALT差异无统计学意义(P>0.05);相比健康组,疾病组的Lym、PLT明显更低,其余指标均更高(P<0.05)。轻症组和重症组性别、年龄、病程、临床症状(发热、咳嗽、咳痰)发生率、WBC、PLT、AST、ALT、Mb、CK-MB差异无统计学意义(P>0.05);相比于轻症组,重症组患儿的呼吸困难发生率、Mon、MLR、PLR、CRP、IL-6、PCT、LDH明显更高(P<0.05),Lym更低(P<0.05)。经过二元Logistic回归分析显示,MLR、PLR、CRP、IL-6、LDH是儿童CAP重症的独立危险因素。结论MLR、PLR可以作为评估儿童CAP病情严重程度的参考指标,且MLR、PLR、CRP、IL-6、LDH是其独立危险因素。
Objective To explore the correlation and risk factor analysis between serum monocyte to lymphocyte ratio(MLR),platelet to lymphocyte ratio(PLR)and disease severity in children with community acquired pneumonia(CAP).Methods 157 pediatric CAP patients admitted to our hospital from December 2021 to December 2022 were selected as the study subjects and assigned to the disease group.According to the severity of the condition,it is divided into mild illness group(n=119)and severe illness group(n=38).At the same time,60 healthy children who underwent physical examinations in our hospital were selected as the health group.The relevant indicators were compared between the disease group and the health group,as well as the mild and severe groups,and use logistic binary regression correlation analysis to analyze the influencing factors.Results There was no statistically significant difference in gender,age,and ALT between the disease group and the healthy group(P>0.05);Compared with the healthy group,the Lym and PLT in the disease group were significantly lower,while other indicators were higher(P<0.05).There was no statistically significant difference in gender,age,course of disease,incidence of clinical symptoms(fever,cough,expectoration),WBC,PLT,AST,ALT,Mb,CK-MB between the mild and severe groups(P>0.05);Compared with the mild group,the incidence of dyspnea,Mon,MLR,PLR,CRP,IL-6,PCT,and LDH in the severe group were significantly higher(P<0.05),Lym was significantly lower(P<0.05).According to binary logistic regression analysis,MLR,PLR,CRP,IL-6,and LDH are independent risk factors for severe CAP in children.Conclusion MLR and PLR can be used as reference indicators to evaluate the severity of pediatric CAP,and MLR,PLR,CRP,IL-6,and LDH are independent risk factors.
作者
王婧文
王学莲
底建辉
WANG Jingwen;WANG Xuelian;DI Jianhui(Department of Pediatrics,Daxing District People's Hospital of Beijing,Beijing 102699,China)
出处
《中国实验诊断学》
2023年第10期1170-1174,共5页
Chinese Journal of Laboratory Diagnosis
