摘要
糖酵解是原发性肝癌代谢重编程过程中重要的生物学事件,其机制主要受糖酵解途径中的关键限速酶,包括己糖激酶(hexokinase,HK)、丙酮酸激酶(pyruvate kinase,PK)、磷酸果糖激酶(phosphofructokinase,PFK)和乳酸脱氢酶(lactate dehydrogenase,LDH)所调节,并可通过葡萄糖转运体(glucose transporter,GLUT)、单羧酸转运蛋白(monocarboxylate transporter,MCT)、PI3K/AKT/mTORC信号通路和缺氧诱导因子(hypoxia-inducible factor,HIF)等多种环节机制进行调控。越来越多的研究证明,糖酵解关键酶及调节因子在肝细胞癌(hepatocellular carcinoma,HCC)细胞增殖、侵袭、转移、免疫逃逸及耐药等方面发挥重要作用。当前随着对于糖酵解机制的深入研究,针对抑制糖酵解的临床治疗已成为新型治疗HCC策略的方法。本文旨在从糖酵解重要关键酶及调节因子参与原发性肝癌发生与发展的研究进展方面作一综述,以期为肝癌的预防和治疗提供一些新的帮助。
Glycolysis is an important biological event in the metabolic reprogramming process of primary liver cancer.Its is mainly regulated by key rate-limiting enzymes in the glycolysis pathway,including hexokinase(HK),pyruvate kinase(PK),phosphofructokinase(PFK),and lactate dehydrogenase(LDH).Moreover,it can also be regulated by multiple mechanisms such as glucose transporters(GLUTS),monocarboxylic acid transporters(MCT),PI3K/AKT/mTORC signaling pathway and hypoxia induction factor(HIF).More and more studies have proved that key glycolytic enzymes and regulatory factors play important roles in hepatocellular carcinoma(HCC)cell proliferation,invasion,metastasis,immune escape,and drug resistance.Currently,with the continuous in-depth research on the mechanism of glycolysis,clinical therapies targeting glycolysis has become a new therapeutic strategy for HCC treatment.This article aims to summarize the research progress of key glycolytic enzymes and regulatory factors in the occurrence and development of primary liver cancer,hoping to provide help for the prevention and treatment of liver cancer.
作者
黄永林
宋振恒
王明刚
毛德文
HUANG Yonglin;SONG Zhenheng;WANG Minggang;MAO Dewen(Department of Hepatic Disease,The First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine,Nanning 530000,Guangxi Zhuang Autonomous Region,China)
出处
《肿瘤》
CAS
北大核心
2023年第11期895-904,共10页
Tumor
基金
广西自然科学基金资助项目(2022XNSFAA035460)
广西自然基金创新团队资助项目(2018GXNSFGA281002)
广西中医药大学及第一附属医院博士启动基金(2020BS026)
关键词
肝癌
糖酵解
关键限速酶
调节因子
Liver cancer
Glycolysis
Key rate-limiting enzymes
Regulatory factors
作者简介
Correspondence to:王明刚,E-mail:wmgyx2012@163.com
