摘要
目的了解酒精依赖综合征患者血清生化指标水平及其早期预测价值。方法对212例酒精依赖综合征患者(研究组)和185名健康志愿者(对照组)的临床资料进行回顾性分析,比较两组受试者的年龄及血清生化指标[谷丙转氨酶(ALT)、谷草转氨酶(AST)、乳酸脱氢酶(LDH)、总胆汁酸(TBA)、总蛋白(TP)、同型半胱氨酸(HCY)、尿酸(UA)、胱抑素C(Cys-C)、胆碱酯酶(CHE)、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、葡萄糖(GLU)]。采用Logistic回归分析探讨血清生化指标与酒精依赖综合征发病的关系,采用Spearman分析探讨血清生化指标与饮酒情况的关系,绘制受试者工作特征(ROC)曲线分析AST、TP、HDL-C、HCY、Cys-C对酒精依赖综合征的早期预测价值。结果研究组受试者血清ALT、AST、LDH、TBA、HDL-C、HCY、Cys-C水平高于对照组,年龄及血清CHE、TP、TG、LDL-C、GLU水平低于对照组(P<0.01)。回归分析结果显示,AST、TP、HDL-C、HCY、Cys-C均是酒精依赖综合征的影响因素(P<0.05或0.01);Spearman相关分析结果显示,酒精依赖综合征患者TP水平与饮酒时间、成瘾时间呈负相关(P<0.05),Cys-C水平与饮酒时间、成瘾时间呈正相关(P<0.01)。ROC曲线分析结果显示,AST、TP、HDL-C、HCY、Cys-C联合预测酒精依赖综合征的曲线下面积为0.981,95%CI为0.961~0.992,灵敏度和特异度分别为92.61%、96.22%,均优于单项指标预测价值(P<0.05)。结论AST、TP、HDL-C、HCY、Cys-C是预测酒精依赖综合征的有效指标,其联合预测价值较高,对酒精依赖综合征的辅助诊断及临床治疗具有一定的临床应用价值。
Objective To investigate serum biochemical indicators levels and their early predictive value in patients with alcohol dependence syndrome(ADS).Methods The clinical data of 212 ADS patients(research group)and 185 healthy volunteers(control group)were retrospectively analyzed.Ages and levels of such serum biochemical indicators were compared between two groups as(alanine transaminase[ALT],aspartate transaminase[AST],lactate dehydrogenase[LDH],total bile acid[TBA],total protein[TP],homocysteine[HCY],uric acid[UA],cystatin C[Cys-C],cholinesterase[CHE],total cholesterol[TC],triglyceride[TG],high-density lipoprotein cholesterol[HDL-C],low-density lipoprotein cholesterol[LDL-C],and glucose[GLU]).Spearman analysis was used to explore the relationships between serum indicators and ADS onset,receiver operating characteristic(ROC)curve plotted to analyze the early predictive values of AST,TP,HDL-C,HCY,and Cys-C for the ADS.Results The levels of ALT,AST,LDH,TBA,HDL-C,HCY and Cys-C were higher,age and the levels of CHE,TP,TG,LDL-C and GLU were lower in study than control group(P<0.01).Regression analysis showed that AST,TP,HDL-C,HCY and Cys-C were all influencing factors of the ADS(P<0.05 or 0.01).Spearman correlation analysis showed that TP level was negatively associated with drinking time and addiction time(P<0.05)and Cys-C positively with them(P<0.01).ROC curve analysis results showed that the area under the ROC curve of the combination prediction of serum AST,TP,HDL-C,HCY and Cys-C was 0.981,95%CI:0.961~0.992,sensitivity and specificity were respectively 92.61%and 96.22%,and which were better than the prediction value of single index(P<0.05).Conclusion The AST,TP,HDL-C,HCY and Cys-C are effective indicators for predicting the ADS and the predictive value of their combination is higher,which has a certain clinical application value to auxiliary diagnosis and clinical treatment of the ADS.
作者
王艳婕
曹威
李杰
邵咏
张付平
Wang Yanjie;Cao Wei;Li Jie;Shao Yong;Zhang Fuping(The Second Affiliated Hospital of Xinxiang Medical University,Xinxiang 453002,Henan,China;不详)
出处
《临床心身疾病杂志》
2025年第1期7-11,共5页
Journal of Clinical Psychosomatic Diseases
基金
河南省科技攻关项目(编号232102310031)。
关键词
酒精依赖综合征
血清生化指标
预测价值
alcohol dependence syndrome
serum biochemical indicator
predictive value
作者简介
王艳婕,女,38岁,汉族,硕士,中级职称。主要研究成果:发表专业论文3篇。研究方向:临床生化检验;通讯作者:张付平,博士(Email:zhangfuping2141@163.com)。
