摘要
激素受体阳性、人表皮生长因子受体2型阴性(HR^(+)/HER2^(-))乳腺癌是最常见的乳腺癌分子亚型,可表现为术后10~15年以上的迟发性复发,且其肺转移病灶需与原发性肺癌相鉴别。本文报道1例HR^(+)/HER2^(-)乳腺癌术后16年迟发性肺转移致霍纳综合征患者,采用^(18)F-FDG PET/CT难以判断肿瘤来源,穿刺活检风险高,经北京协和医院新型^(18)F-FES PET/CT无创功能性诊断为乳腺癌肺上叶雌激素受体(estrogen receptor,ER)阳性转移,给予CDK4/6抑制剂+芳香化酶抑制剂内分泌解救治疗后获得缓解。本文总结该患者的临床表现及诊治经过,为新型^(18)F-FES PET/CT评估乳腺癌患者转移灶的ER表达情况及指导后续个体化诊疗提供借鉴。
Hormonal receptor positive human epidermal receptor 2 negative(HR^(+)/HER2^(-))commonest molecular subtype of breast cancer(BC).Patients with HR^(+)/HER2^(-)BC may manifest clinically a late recurrence whose BC metastasizes 10-15 years post-operatively.We report one case who presented with pulmonary mass in upper lobe of lung and Horner syndrome 16 years after BC surgery.FDG PET/CT suggested pulmonary malignancy but could not differentiate between primary or metastatic cancer when invasive biopsy was quite risky.Novel 18 F-FES PET/CT facilitated the non-invasive functional diagnosis of estrogen-receptor positive(ER^(+))pulmonary metastasis of BC,and the patient experienced partial response(PR)after CDK4/6 inhibitor and aromatase inhibitor as endocrine therapy.This article reviews the diagnosis and treatment process of this case,to provide guidance for non-invasive global evaluation of ER status among metastatic HR^(+)/HER2^(-)BC patients with ^(18)F-FES PET/CT.
作者
姚儒
郝志鑫
屈洋
张超
李唯佳
郎洁
潘博
周易冬
孙强
霍力
YAO Ru;HAO Zhixin;QU Yang;ZHANG Chao;LI Weijia;LANG Jie;PAN Bo;ZHOU Yidong;SUN Qiang;HUO Li(Department of Breast Surgery,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100730,China;Department of Nuclear Medicine,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100730,China;Department of Breast Surgery,Beijing LongFu Hospital,Beijing 100010,China)
出处
《协和医学杂志》
CSCD
北大核心
2024年第3期702-707,共6页
Medical Journal of Peking Union Medical College Hospital
基金
中央高水平医院临床科研专项(2022-PUMCH-A-165,2022-PUMCH-B-039)
中国医学科学院医学与健康科技创新工程(2021-I2M-1-014)。
作者简介
通信作者:潘博,E⁃mail:panbopumc@163.com;通信作者:周易冬,E⁃mail:zhouyd@pumch.cn;通信作者:霍力,E⁃mail:huoli@pumch.cn。
