摘要
目的研究健脾益肾祛瘀化痰法对2型糖尿病主要心血管疾病危险因素的干预情况。方法采用临床随机对照试验,将就诊于银川市中医医院内分泌科并且符合纳入标准的患者随机分为试验组35例与对照组35例,两组分别给予降糖、降压、降脂、饮食及运动常规基础治疗,试验组在基础治疗上联合以健脾益肾祛瘀化痰法为治则的软化动脉胶囊。观察周期为90 d,检测记录治疗前后患者体质量指数(BMI)、收缩压(SBP)、舒张压(DBP)、空腹血糖(FPG)、餐后2 h血糖(2 hPG)、糖化血红蛋白(HbA1c)、低密度脂蛋白(LDL)、甘油三酯(TG)、总胆固醇(TC)、超敏C反应蛋白(hs-CRP)、尿微量白蛋白(UMA)的变化情况,比较两组中医证候疗效。结果90 d治疗周期中无脱落病例。经治疗,试验组中医疗效有效率明显高于对照组(P<0.05),试验组SBP、DBP、FPG、2hPG、HbA1c、LDL、TG、TC均低于对照组(P<0.05),hs-CRP相较于对照组明显下降(P<0.05),UMA较对照明显改善(P<0.05)。两组在试验期间均为出现明显不良反应,未发生急性心血管事件。结论健脾益肾祛瘀化痰法对2型糖尿病主要心血管疾病危险因素具有保护作用。
Objective To study the intervention of strengthening the spleen and kidney,eliminating blood stasis and resolving phlegm on major cardiovascular disease risk factors in patients with type 2 diabetes mellitus.Methods In a randomized controlled trial,patients attending the Department of Endocrinology of Yinchuan Hospital of Traditional Chinese Medicine and meeting the inclusion criteria were randomly divided into 35 cases in the experimental group and 35 cases in the control group,and the two groups were given conventional treatments of lowering glucose,lowering blood pressure,lowering lipids,diet,and exercise,the experimental group was given the Ruanhua dongmai capsule,which was based on the principle of strengthening the spleen and the kidneys and eliminating blood stasis and resolving phlegm.The observation period was 90 days,The changes of body mass index(BMI),systolic blood pressure(SBP),diastolic blood pressure(DBP),fasting plasma glucose(FPG),2-hour post-prandial plasma glucose(2 hPG),glycosylated hemoglobin(HbA1c),low-density lipoprotein(LDL),triglyceride(TC),total cholesterol(TG),hypersensitive C-reactive protein(hs-CRP),and urinary micro-albumin(UMA)were recorded before and after the treatments,and the efficacy of Chinese medicine evidence was compared between the two groups of patients.Result-s There was no shedding case in the 90-day treatment cycle.After treatment,the effective rate of TCM efficacy of the patients in the test group was significantly higher than that of the control group(P<0.05).Compared with the control group,the blood pressure(SBP,DBP),blood glucose level(FPG,2hPG,HbA1c),and lipid level(LDL,TG,TC)of the patients in the test group decreased significantly(P<0.05),and the inflammatory index(hs-CRP)of the test group decreased significantly(P<0.05)compared to the control group,while the UMA of patients in the test group improved significantly compared with the con-trol(P<0.05).There were no significant adverse reactions and no acute cardiovascular events in both groups during the trial period.Conclusion It was initially observed that the method of strengthening the spleen and benefiting the kidney,expelling blood stasis and resolving phlegm had a protective effect on the major cardiovascular disease risk factors of patients with type 2 di-abetes mellitus,which is worthy of clinical promotion and application.
作者
颜青
董慧杰
宋丽
党翔
张恒耀
党毓起
YAN Qing;DONG Huijie;SONG Li;DANG Xiang;ZHANG Hengyao;DANG Yuqi(The Traditional Chinese Medicine Hospital of Yinchuan,Yinchuan 750001,Ningxia,China)
出处
《实用中医内科杂志》
2024年第1期64-67,共4页
Journal of Practical Traditional Chinese Internal Medicine
基金
宁夏医科大学科学研究基金资助项目一般项目(XM2020115)。
关键词
健脾益肾祛瘀化痰法
2型糖尿病
心血管疾病危险因素
strengthening the spleen and kidney
expelling blood stasis and resolving phlegm
type 2 diabetes mellitus
cardiovascular disease risk factors
作者简介
颜青(1990-),女,宁夏石嘴山人,主治医师,硕士,研究方向:中医药防治糖尿病及其并发症;通讯作者:党毓起(1963-),男,宁夏银川人,主任医师,学士,研究方向:中医药防治糖尿病及其并发症。E-mail:dangyuqi@126.com。
