摘要
目的 分析胃蛋白酶原Ⅰ/Ⅱ、胃泌素联合血常规检查对萎缩性胃炎和胃癌的鉴别诊断价值。方法 选取20例胃癌患者作为试验一组,50例萎缩性胃炎患者作为试验二组,另选取20例健康者作为对照组。三组均接受胃蛋白酶原Ⅰ/Ⅱ、胃泌素、血常规及胃镜检查,将胃镜作为金标准,与胃蛋白酶原Ⅰ/Ⅱ、胃泌素联合血常规检查结果进行对照,分析胃蛋白酶原Ⅰ/Ⅱ、胃泌素联合血常规检查对胃癌的诊断效能;对比三组胃蛋白酶原Ⅰ/Ⅱ、胃泌素、血常规检查的结果;对比胃蛋白酶原Ⅰ/Ⅱ、胃泌素联合血常规检查与胃镜检查的费用。结果 试验一组胃蛋白酶原Ⅰ/Ⅱ(6.21±0.64)、血红蛋白(101.43±16.02)g/L低于试验二组的(7.45±0.85)、(122.14±17.56)g/L和对照组的(10.25±1.34)、(145.56±18.95)g/L,胃泌素-17(G-17)(19.21±2.03)pmol/L、白细胞计数(12.04±1.34)×10^(9)/L高于试验二组的(15.14±1.65)pmol/L、(10.01±1.02)×10^(9)/L和对照组的(11.03±1.22)pmol/L、(6.78±0.81)×10^(9)/L(P<0.05);试验二组胃蛋白酶原Ⅰ/Ⅱ、血红蛋白低于对照组,胃泌素-17、白细胞计数高于对照组(P<0.05)。胃镜诊断阳性、阴性例数分别为20、50例。胃蛋白酶原Ⅰ/Ⅱ、胃泌素联合血常规检查确诊阳性、阴性例数分别为19、51例,诊断准确度、灵敏度、特异度分别为98.57%、95.00%、100.00%。胃蛋白酶原Ⅰ/Ⅱ、胃泌素联合血常规的检查费用为(358.79±40.28)元,胃镜的检查费用为(750.45±100.69)元;胃蛋白酶原Ⅰ/Ⅱ、胃泌素联合血常规的检查费用明显少于胃镜(t=34.261,P=0.000<0.05)。结论 胃蛋白酶原Ⅰ/Ⅱ、胃泌素联合血常规检查可作为萎缩性胃炎、胃癌鉴别诊断的重要指标,其诊断结果与胃镜检查接近,值得应用。
Objective To analyze the value of pepsinogenⅠ/Ⅱand gastrin combined with routine blood examination in differential diagnosis of atrophic gastritis and gastric cancer.Methods 20 patients with gastric cancer were selected as the experimental group 1,50 patients with atrophic gastritis as the experimental group2,and another 20 healthy subjects as the control group.All subjects in the three groups received pepsinogenⅠ/Ⅱ,gastrin and routine blood examination and gastroscopy.The gastroscopy was used as the gold standard to compare with the results of pepsinogenⅠ/Ⅱand gastrin combined with blood routine examination,and the diagnostic efficacy of pepsinogenⅠ/Ⅱand gastrin combined with blood routine examination was analyzed.The results of pepsinogenⅠ/Ⅱ,gastrin and blood routine examination were compared among the three groups,and the cost of pepsinogenⅠ/Ⅱ,gastrin combined with routine blood examination and gastroscopy was compared.Results In experimental group 1,the pepsinogenⅠ/Ⅱwas (6.21±0.64) and hemoglobin was (101.43±16.02) g/L,which were lower than experimental group 2[(7.45±0.85) and (122.14±17.56) g/L]and control group[(10.25±1.34) and (145.56±18.95) g/L];and the gastrin-17 (G-17) was (19.21±2.03) pmol/L and white blood cell count was (12.04±1.34)×10^(9)/L,which were higher than experimental group 2[(15.14±1.65) pmol/L and (10.01±1.02)×10^(9)/L]and control group[(11.03±1.22) pmol/L and (6.78±0.81)×10^(9)/L](P<0.05).The levels of pepsinogenⅠ/Ⅱand hemoglobin in experimental group 2 were lower than those in control group,while gastrin-17 and white blood cell counts were higher than those in control group (P<0.05).The number of positive and negative cases by gastroscopy were 20 and 50 respectively.The number of positive and negative cases by pepsinogenⅠ/Ⅱand gastrin combined with blood routine examination were 19 and 51,respectively.The diagnostic accuracy,sensitivity and specificity were 98.57%,95.00%and 100.00%,respectively.The cost of pepsinogenⅠ/Ⅱand gastrin combined with blood routine examination was (358.79±40.28) yuan,and the cost of gastroscopy was (750.45±100.69) yuan;the cost of pepsinogenⅠ/Ⅱand gastrin combined with blood routine examination was significantly less than that of gastroscopy (t=34.261,P=0.000<0.05).Conclusion PepsinogenⅠ/Ⅱand gastrin combined with blood routine examination can be used as important indexes for differential diagnosis of atrophic gastritis and gastric cancer,and their diagnostic efficacy is close to that of gastroscopy,which is worthy of application.
作者
区义红
麦哲林
罗尧新
张影霞
任瑞芬
OU Yi-hong;MAI Zhe-lin;LUO Yao-xin(Gastroenterology Department,Heshan People's Hospital,Heshan 529700,China)
出处
《中国实用医药》
2024年第2期75-78,共4页
China Practical Medicine
基金
2021年度广东省江门市医疗卫生科技计划项目(项目编号:2021YL11004)。
关键词
胃蛋白酶原Ⅰ/Ⅱ
胃泌素
血常规
胃镜
萎缩性胃炎
胃癌
PepsinogenⅠ/Ⅱ
Gastrin
Routine blood examination
Gastroscope
Atrophic gastritis
Gastric cancer
