摘要
颞下颌关节骨关节炎(temporomandibular joint osteoarthritis,TMJOA)是颞下颌关节紊乱病(temporomandibular diseases,TMD)的重症形式。关节软骨退变是TMJOA早期最典型的病理学特征之一,软骨细胞死亡是软骨退变中的核心事件。相比较于凋亡和自噬,新型细胞死亡模式——程序性坏死(necroptosis)发生后所释放的损伤相关分子模式(damage associated molecular patterns,DAMPs)能够对周围细胞、软骨基质造成进一步损害,并且可能形成肿瘤坏死因子-α(tumor necrosis factorα,TNF-α)-necroptosis-DAMPs-TNF-α恶性环路,对软骨造成更大的破坏。因此,本文试对Necroptosis在OA软骨退变中的研究作一综述,以期为揭示TMJOA病变机制提供新的认识。
Temporomandibular osteoarthritis(TMJOA)is a severe form of temporomandibular disorder(TMD).Articular cartilage degeneration is one of the most typical pathological features in primary TMJOA,and chondrocyte death is the core event in cartilage degeneration.Compared with apoptosis and autophagy,the release of damage associated molecular patterns(DAMPs)after the occurrence of necroptosis,which is a new type of cell death,do further harm to chondrocytes and cartilage extracellular matrix.The TNF-α-Necroptosis-DAMPs-TNF-αvicious circle may result in extensive destruction to cartilage.Therefore,this article briefly reviews related researches on necroptosis in cartilage degeneration of OA in order to provide new understanding concerning the pathogenesis of TMJOA.
作者
何峰
于世宾
HE Feng;YU Shibin(State Key Laboratory of Military Stomatology&National Clinical Research Center for Oral Diseases&Shaanxi International Joint Research Center for Oral Diseases,Department of Oral Anatomy and Physiology and TMD,School of Stomatology,the Fourth Military Medical University,Xi'an 710032,China)
出处
《口腔医学研究》
CAS
CSCD
北大核心
2021年第1期15-18,共4页
Journal of Oral Science Research
基金
国家自然科学基金(编号:81970953)
陕西省重点研发计划一般项目(编号:2019SF-102)。
作者简介
何峰(1991~),男,安徽安庆人,硕士在读,研究方向:口腔基础医学;通讯作者:于世宾,E-mail:yushibin@fmmu.edu.cn。
