摘要
目的:观察双氯芬酸钠联合玻璃酸钠治疗眼科术后干眼症的临床疗效。方法:选择我院眼科术后不同程度干眼症患者94例94眼,并将其随机分为研究组和对照组各47例47眼,对照组患者在常规治疗的基础上联合玻璃酸钠滴眼液治疗,研究组患者在对照组的基础上配合双氯芬酸钠滴眼液治疗。比较两组患者治疗效果、干眼症状调查问卷评分、检测角膜荧光染色(corneal fluorescein staining,CFS)、泪膜破裂时间(tear film break-up time,BUT)及泪液分泌(SchirmerⅠtest,SⅠt)情况。结果:治疗后两组患者干眼症临床症状调查得分、CFS得分均明显低于治疗前,差异具有统计学意义(P<0.05),BUT及SⅠt情况比治疗前增加,差异具有统计学意义(P<0.05);研究组患者在治疗后干眼症临床症状调查得分、CFS得分、BUT及SⅠt结果均优于对照组患者,两组之间差异具有统计学意义(P<0.05)。研究组患者的治疗总有效率(98%)明显优于对照组(74%),差异具有统计学意义(P<0.05)。结论:对眼科手术后干眼症患者在常规治疗基础上给予双氯芬酸钠眼液联合玻璃酸钠眼液治疗可以有效缓解患者干眼的临床症状,减少角膜荧光染色情况,增加泪膜破裂时间及泪液分泌量。
AIM： To study and analyze the clinical efficacy of diclofenac sodium eye drops combined with sodium hyaluronate eye drops in treating dry eyes after ophthalmic surgery. METHODS： Totally 94 eyes from 94 patients with dry eyes were slected, and they were randomly divided into orbervation group and control group. Foutyseven patients in the control group using conventional treatment combined with sodium hyaluronate eye drops. Other 47 patients in orbervation group were treated with diclofenac sodium eye drops on the basis of control group. We compared symptoms, fluorescein station, tear film break time, Schirmer I test between the two groups. RESULTS： Compared with before treatment, patients of both groups with sympotom, fluorescein station score, BUT, and Schirmer I test were significantly improved （ P〈 0. 05）. At the same time, sympotom, fluorescein station score, BUT and Schirmer I test of control group were better than observation group （P〈 0.05）. The cure rates of the orbervation group （98%） were more significant than control group （74%） （P〈0.05）. CONCLUSION ： Diclofenac sodium eye drops combined with sodium hyaluronate eye drops have significant efficacy in treatment of dry eyes after ophthalmic surgery, which can effectively relieve clinical symptoms, improve BUT and Schirmer I test.
出处
《国际眼科杂志》
CAS
2017年第7期1368-1370,共3页
International Eye Science
关键词
干眼症
双氯芬酸钠眼液
玻璃酸钠眼液
联合治疗
临床疗效
dry eye
diclofenac sodium
sodium hyaluronate eyedrops
combined therapy
clinical curative effect
作者简介
刘李平，副主任医师，研究方向：眼表疾病。通讯作者：刘李平．xjws．llp126@qq．com
