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不同剂量氨甲环酸对脊柱手术患者出血量的影响 被引量:8

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摘要 目的观察不同剂量氨甲环酸(TXA)对脊柱手术患者出血量的影响。方法将60例择期行脊柱手术患者随机分为A、B、C组各20例,A、B组麻醉诱导后切皮前15 min内分别静注负荷量的TXA 20、10 mg/kg,然后静脉泵注维持量的TXA 2、1 mg/(kg·h)至手术结束;C组同时点静注等量生理盐水。于术前和术毕取血测定Hb、HCT、PLT、PT和APTT,记录术中总出血量、输液量、输血量和尿量。结果与术前比较,三组术毕Hb、HCT、PLT降低(P均<0.05);A、B组术毕Hb、HCT、PLT高于C组(P均<0.05),A组术毕Hb、HCT、PLT高于B组(P均<0.05)。A、B组术中出血量少于C组(P均<0.05),A组术中出血量少于B组(P<0.05);各组术毕PT、APTT组间比较,P均>0.05。结论 TXA可减少脊柱手术患者术中出血量,且具有剂量依赖性。
出处 《山东医药》 CAS 2014年第40期62-63,共2页 Shandong Medical Journal
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