摘要
DNA等位基因微卫星不稳定性（microsatelliteinstability，MSI）广泛参与肿瘤的发生与发展，是肿瘤常见的遗传学改变之一。某些染色体或某一染色体的某些特定区域在头颈鳞癌（headandnecksquamouscellcarcinoma，HNSCC）发生发展中存在着高频发的MSI。有些MSI常发生于HNSCC的早期。弄清这些与HNSCC有良好相关性并与许多抑癌基因紧密连锁的微卫星有否等位基因缺失或不稳定性将有助于进一步阐明HNSCC的发生与发展机制。
Gene microsatellite instability (MSI) is widely implicated in the development of many malignancies and is one of the most common genetic alterations in carcinogenesis. Some microsatellite loci of specific chromosomes,such as 3p14-25, 9P21-22,17p13. 1-13. 3, 18P12. 2-22. 3,display at high frequency MSI involving the multistep development and progression of head and neck squamous cell carcinoma (HNSCC). Some MSI happen very early in the progression of head and neck carcinogenesis. To clarify whether there is MSI or allelic loss in specific regions of some chromosome arms,which is well associated with HNSCC and is closely linked with tumor suppressor genes,will further aid in understanding the mechanism in HNSCC progression.
出处
《耳鼻咽喉（头颈外科）》
2000年第3期187-192,共6页
Chinese Arch Otolaryngology-Head Neck Surg
关键词
头颈部肿瘤
鳞状细胞癌
基因
脱氧核糖核酸
Head and neck neoplasms
Carcinoma，squamous cell
Genes
DNA，neoplasms
