低潮气量通气对老年腹部手术肺顺应性及氧合的影响被引量：3

Effect of low tidal volumes on lung compliance and oxygenation in elder patients during abdominal surgery

在线阅读下载PDF

导出

摘要目的研究低潮气量通气对老年人术中肺顺应性(CL)及氧合的影响。方法 40例60岁以上、ASAⅠ或Ⅱ级老年患者,在气管插管全身麻醉下实施择期开腹手术。观察组潮气量(VT)为7 ml/kg预测体质量(PBW);对照组VT为12 ml/kg PBW。分别于插管后5 min(T0)、30 min(T1)、1 h(T2)、3 h(T3)4个时点记录心率(HR)、平均动脉压(MAP)、血氧饱和度(SpO2)、呼气末二氧化碳分压(PETCO2)、气道峰压(Ppeak)、气道平台压(Pplat)、CL;并于各时点桡动脉处抽血测血气指标。结果对照组在机械通气期间,Ppeak、Pplat明显高于观察组(P=0.012,P=0.013);两组CL均随着时间延长呈下降趋势,对照组低于观察组(P=0.012);对照组T3时点PaO2低于观察组(P<0.05)。结论低潮气量通气改善了老年人术中的氧合及CL,能减轻机械通气造成的肺损伤。 Objective To investigate the effect of low tidal volumes on lung compliance （CL） and oxygenation in eld- er patients during abdominal surgery. Methods Forty ASA I or II elder patients, aged over 60 years, scheduled for se- lective abdominal operation under general anesthesia were divided randomly into 2 groups ： group LV （ VT 7 ml/kg PBW） and group C （VT 12 ml/kg PBW）. HR, MAP, SpO2, PETCO2 , Ppeak, Pplat, CL were monitored continuously and recor- ded at 5 min （T0 ）, 30 min （T1 ）, 1 h （T2）, 3 h （ T3 ） after tracheal intubation. Arterial blood gas analysis was performed at the same point. Result Compared with the group C, mechanical ventilation with low tidal volumes had lower peak air- way pressures （Pplat and Ppeak, respectively）, and higher CL and PaO2. Conclusions Mechanical ventilation with low tidal volumes can improve CL and PaO2 in eider patients with abdominal surgery, which alleviates their abdominal injury.

作者朱蔚琳黄中华张学刚何并文黄爱兰李锋胡彦艳秦丹丹

机构地区广西壮族自治区人民医院广西医科大学附属肿瘤医院

出处《山东医药》 CAS 北大核心 2011年第40期66-68,共3页 Shandong Medical Journal

基金广西科技厅科学自然基金(桂科自064006)

关键词机械通气低潮气量肺顺应性老年人 mechanical ventilation low tidal volumes lung compliance aged

分类号 R614.2 [医药卫生—麻醉学]

引文网络
相关文献

参考文献8

1Stüber F,Wrigge H,Schroeder S,et al.Kinetic and reversibility of mechanical ventilation-associated pulmonary and systemic inflammatory response in patients with acute lung injury[J].Intensive Care Med,2002,28(7):834-841.
2OZ Yilmaz.Processing,inversion,and interpretation of seismic data:Volume I and Volume Ⅱ [C] Society of Exploration Geophysicists,2001.
3张红,潘芳,刘芳,冯艺,杨拔贤.盐酸戊乙奎醚对全麻老年患者潮气量和肺顺应性的影响[J].临床麻醉学杂志,2009,25(9):764-766. 被引量：20
4Günther A,Taut F.Tidal volume in mechanical ventilation:the importance of considering predicted body weight[J].Am J Respir Crit Care Med,2008,178(3):315-316.
5Kaynar AM,Houghton AM,Lum EH,et al.Neutrophil elastase is needed for neutrophil emigration into lungs in ventilator-induced lung injury[J].Am J Respir Cell Mol Biol,2008,39(1):53-60.
6Briel M,Meade M,Mercst A,et al.Higher vs lower positive end-ex piratory pressure in patients with acute lung injury and acute respiratory distress syndrome:systematic review and meta-analysis[J].JAMA,2010,303(9):865-873.
7Tusman G,Bohm SH,Tempra A,et al.Effects of recruitment maneuver on atelectasis in anesthetized children[J].Anesthesiology,2003,98(1):14-22.
8Angelo ED,Koutsoukou A,Valle PD,et al.Cytokine release,small airway injury,and parenchymal damage during mechanical ventilation in normal open-chest rats[J].J Appl Physiol,2008,104(1):41-49.