摘要
目的优选成型所需辅料,确定通络微丸成型方法。方法对不同辅料制备的微丸成型难易、流动性、溶出度等比较,筛选出适当的成型辅料,并确定旋转制丸的工艺参数。结果10PEG2000制丸模和5PEG2000或10的阿拉伯胶加大时,该浸膏粉成丸效果较好,微丸的圆整性、流动性、溶出度均较好。微丸加大成型的适宜参数是主机转速100r·min-1,鼓风压力0.04MPa,喷浆速度300g·min-1,饲粉速度1200g·min-1。结论粘合剂的品种选择是中药浸膏粉制备微丸的关键,旋转式制丸技术制备微丸时加大成型的参数应适宜。
AIM ： To choose the proper excipient for molding process of Tongluo Mini-Pill （ Radix Astragali, Radix Augelicae sinensis, Flos longicerae Japonicae, etc） and couplet its production. METHODS ： A variety of excipients properties such as fluidity, solubility and dissolution were compared to select and determine the processing parameters of rotary perlletizer. RESULTS： Recommendation was made applying processing parameters that 10% PEG2000,10% PEG20oo or 10% gum arabic used for excipient,pelletizer had a rotational velosity of 100 rpm. pressure of 0.04 Mpa and feeding rate of 1200 g ·main^-1 CONCLUSION：Selection of excipients is a key to make Tonglu Mini-Pill.
出处
《中成药》
CAS
CSCD
北大核心
2005年第9期1004-1007,共4页
Chinese Traditional Patent Medicine
基金
国家863重大研究计划项目(2003AA2Z3247)
作者简介
狄留庆（1964～）,江苏南京,博士,南京中医药大学副教授,研究方向：中药制剂.025-86798226;E-mail：diliuqing@yahoo.com.cn
