摘要
目的探讨老年住院患者衰弱与认知功能间的相关性,为防治措施提供一定的参考。方法选取2018年11月至2019年7月湖北省中医院老年病科住院患者233例为研究对象,运用老年综合评估问卷调查一般人口学特征及临床特征;Fried衰弱表型(FP)调查衰弱状态;简易精神状态检查量表(MMSE)评估老年患者认知情况,并将老年患者分为认知功能正常组(170例)和认知功能障碍组(63例),统计并分析两组人口统计学及衰弱各分项的差异。结果两组在年龄、MMSE总分、日常生活能力(ADL)及工具性日常生活活动量表(IADL)是否受损、衰弱评分以及是否衰弱间的差异存在统计学意义(P<0.05),即与认知功能正常组比较,年龄越大,MMSE总分越低,ADL及IADL受损,衰弱评分越高,存在衰弱则认知功能越差;而在性别、婚况、文化程度、BMI值、多重用药、共病情况间的差异无统计学意义(P>0.05)。在衰弱各项指标中,两组只有在握力下降及步速下降的差异有统计学意义(P<0.05),即与认知功能正常组相比,握力下降及步速下降的老年患者认知功能越差。校正年龄、性别等混杂因素后提示步速下降与认知功能有关(P<0.05,OR:0.472,95%CI:0.229,0.970)。结论衰弱是住院老年患者认知功能障碍的危险因素,特别对于步速下降的老年患者更应重视其认知功能的评估。
Objective To analyze the relationship between cognitive impairment and frailty in elderly inpatients to provide a reference for the prevention and treatment of the disease in such a population.Methods 233 patients aged 70 years and over from Nov.2018 to Jul.2019 in the Department of Geriatrics of the Hubei Provincial Hospital of Traditional Chinese Medicine were selected,using the Comprehensive Geriatric Assessment to investigate the general situation and clinical characteristics.Frailty phenotype(FP)investigates frailty status and the Mini-Mental State Examination(MMSE)assesses the cognitive status.Patients were divided into normal cognitive function group(n=170)and cognitive impairment group(n=63).The differences in demographics and frailty sub-items between the two groups were collected and analyzed.Results There were statistically significant differences in age,total MMSE score,ADL and IADL damage,frailty score,and frailty(P<0.05),that is,compared with the normal cognitive function group,elderly patients with the older age,the lower score of MMSE,the impairment of ADL and IADL,the higher the frailty score,and be diagnosed as frail have worse cognitive function;between the two groups.There were no statistically significant differences in gender,marriage status,education level,BMI value,multiple medications,and comorbid conditions(P>0.05).Among the various indicators of weakness,the difference between the two groups was statistically significant only in the decline in grip strength and pace(P<0.05),compared with the normal cognitive function group,elderly patients with decreased grip strength and decreased pace have worse cognitive function.After adjusting for confounding factors such as age and gender,it was suggested that the decline in pace was related to cognitive function(P<0.05,OR:0.472,95%CI:0.229,0.970).Conclusions Frailty is a risk factor for cognitive dysfunction in elderly patients,especially for reduced pace,the evaluation of their cognitive function should be paid more attention to the elderly patients with the decline in pace.
作者
曾珊珊
ZENG Shanshan(The First Clinical College,Hubei University of Traditional Chinese Medicine,Wuhan 430061,China)
出处
《湖北民族大学学报（医学版）》
2021年第1期46-49,共4页
Journal of Hubei Minzu University(Medical Edition)
基金
湖北省自然科学基金重点项目(2015CFA089)
湖北省中医院老年呆病“五专”项目建设
中国中医科学院中医基础理论研究所自主选题“院所协同创新科研专项基金”(YZ-1852)。
关键词
认知功能
衰弱
认知衰弱
老年
影响因素
Cognitive function
Frailty
Cognitive frailty
Elderly patients
Factors
作者简介
曾珊珊,女,硕士研究生,研究方向:中西医结合治疗心脑血管疾病。
