摘要
目的探讨枸地氯雷他定对比氯雷他定治疗慢性荨麻疹的有效性以及安全性,为临床合理用药提供决策参考。方法检索数据库包括:Medline、CNKI、维普、万方等,关键词采用"疗效","枸地氯雷他定","氯雷他定"和"慢性荨麻疹",限定年限为1997-2017年,由两位研究者按照纳入排除标准独立筛选文献,进行文献质量评估和数据提取,结果采用Stata14.0软件进行Meta分析。结果本文纳入4篇临床研究,共466例患者。Meta分析结果显示,在有效性方面,枸地氯雷他定治疗慢性荨麻疹的临床疗效优于氯雷他定,其28天治愈率和28天有效率的OR值分别为:1.98(95%CI:1.15~3.42)和2.69(95%CI:1.49~4.87);在安全性方面,枸地氯雷他定相比氯雷他定治疗慢性荨麻疹在不良反应发生率组间差异无统计学意义:OR=0.43(95%CI:0.18~1.02),最常见的不良反应为嗜睡、口干、头晕、恶心。结论枸地氯雷他定治疗慢性荨麻疹的临床有效性优于氯雷他定,而安全性两者差异无统计学意义。
Objective To discuss the efficacy and safety of desloratadine citrate disodium in the treatment of chronic urticaria compared with loratadine,and to provide reference for clinical rational drug use.Methods Databases including PubMed（Medline）,CNKI,Wangfang and Weipu were used for articles.The keywords were ＂efficacy＂,＂livatidine＂,＂loratadine＂ and ＂chronic urticaria＂,with a limited age of 1997-2017,two investigators screened the literature according to the inclusion criteria and carried out the quality assessment and data extraction of the literature.Meta analysis of the results was performed using stata14.0 software.Results This article included four clinical studies with 466 patients.Meta analysis showed that the efficacy of desloratadine citrate disodium in the treatment of chronic urticaria was superior to that of loratadine.The 28-day cure rate and the 28-day effective rate OR were 1.98（95%CI： 1.15～3.42）and 2.69（95%CI： 1.49～4.87）.In terms of safety,there was no significant difference in the incidence of adverse reaction rate in the treatment of chronic urticaria between desloratadine citrate disodium and loratadine： OR=0.43（95%CI： 0.18～1.02）.The most common adverse reactions were lethargy,dry mouth,dizziness,and nausea.Conclusion The clinical efficacy of desloratadine citrate disodium in the treatment of chronic urticaria was superior to that of loratadine,but there was no significant difference in safety between the two treatments.
出处
《中国皮肤性病学杂志》
CAS
CSCD
北大核心
2018年第2期135-139,共5页
The Chinese Journal of Dermatovenereology
基金
中央高校基本科研业务费专项资金资助(21616324)
作者简介
[通讯作者]张田甜，E-mail：zhangtiantian@jnu．edu．cn
