摘要
目的探讨振动对脑组织去甲肾上腺素和多巴胺的影响及其与振动性神经病发病机制的关系。方法将家兔按不同强度分组进行接振45 d后,测定对照组和实验组家兔脑组织中的去甲肾上腺素(noradrenalin,NE)和多巴胺(dopamine,DA)含量。结果与对照组比较,各实验组NE含量显著降低(P<0.01);实验组DA含量显著降低,其中,中、高剂量组与对照组比较,差异有统计学意义(P<0.01)。结论振动对中枢神经系统产生影响,其可能与振动性神经病的发病机制有关。
Objective To study the effects of local vibration on noradrenalin and dopamine of rabbit brain tissues, and its association with vibration-induced neuropathy. Methods Rabbits were randomly divided into 4 groups and exposed to vibration at different levels for 45 days. After the test, the contents of noradrenalin and dopamine in brain tissues were measured in each group. Results Compared with the control group, the concentration of noradrenalin in all exposure groups decreased significantly （P〈0.01）. Dopamine of high and medium exposure groups also decreased significantly （P〈0.01）. Conclusions The NE and DA changes in brain tissue might be related to vibration-induced neuropathy.
出处
《工业卫生与职业病》
CAS
CSCD
北大核心
2009年第1期12-13,共2页
Industrial Health and Occupational Diseases
关键词
局部振动
振动性神经病
去甲肾上腺素
多巴胺
实验研究
Local vibration
Vibration-induced neuropathy
Noradrenalin
Dopamine
Experimental study
作者简介
苏大禹（1979-），男，医师。
