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全氟辛酸铵毒性研究进展 被引量：9

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摘要 著名的杜邦不粘锅特氟龙（Teflon）事件已经结束，确让我们记住了应十分关注的一个化学物质——全氟辛酸铵（perfluorooctanoate，PFOA）。那么，什么是PFOA？ PFOA对动物是否有害？对环境和环境生物的污染状况如何？最重要的是PFOA对人体是否有害，譬如是否有致癌等作用以及在人群血液中的残留情况如何？本文将根据目前的研究情况对上述问题做一综述。
作者 陈江 黄幸纾 傅剑云
机构地区 浙江省疾病预防控制中心
出处 《职业与健康》 CAS 2006年第16期1244-1247,共4页 Occupation and Health
关键词 全氟辛酸铵 毒性 研究进展
分类号 R595 [医药卫生—内科学]
作者简介 陈江，男，医师，主要从事环境毒理实验研究工作。
  • 相关文献

参考文献38

  • 1Kudo N,Kawashima Y.Toxicity and toxicokinetics of perfluorooctanoic acid in humans and animals.J Toxical Sci,2003,28:49-57.
  • 2Han X,Snow TA,Kemper RA,et al.Binding of perfluorooctanoic acid to rat and human plasma proteins.Chem Res Toxicol,2003,16:775-781.
  • 3Kudo N,Katakura M,Sato Y,et al.Sex hormone-regulated renal transport of perfluorooctanoic acid.Chem Biol Interact,2002,139:301-316.
  • 4York RG.Oral (garage) two-generation (one litter per generation) reproduction study of ammonium perfluorooctanoate (APFO) in rats.Reviewed in US EPA AR226-1092,2002.
  • 5Environmental Protection Agency (EPA).Revised draft hazard assessment of perfiuorooctanoic acid and its salts.EPA Administrative Record AR220-1136.
  • 6Sibinski LJ.Two-Year oral (diet) toxicity/carcinogenicity study of fluorochemicai FC-143 (perfluorooctane ammonium carboxylate) in rats.Reviewed in US EPA"Revised Draft PFOA Hazard Assessment-Robust Study Annex" AR226-1137.1987:260-267.
  • 7Biegel LB,Liu RC,Hurtt ME,et al.Effects of ammonium perfluorooctanoate on Leydig cell function:in vitro,in vivo,and ex vivo studies.Toxicol Appl Pharmacol,1995,134:18-25.
  • 8Mehrotra K,Morgenstem R,Lundqvist G,et al.Effects of peroxisome proliferators and/or hypothyroidism on xenobiotic-metabolizing enzymes in rat testis.Chem Biol Interact,1997,104(2-3):131-145.
  • 9Yang Q,Abedi-Valugerdi M,Xie Y,et al.Potent suppression of the adaptive immune response in mice upon dietary exposure to the potent peroxisome proliferator,perfiuorooctanoic acid.int lmmunopharmacol,2002,2:389-397.
  • 10Yang Q,Xie Y,Depierre JW.Effects of peroxisome proliferators on the thymus and spleen of mice.Clin Exp Immunol,2000,122:219-226.

二级参考文献43

  • 1[1]Starkov AA, Wallace KB. Structural determinants of fluorochemicalinduced mitochondrial dysfunction. Toxicol Sci, 2002, 66(2 ): 244-252
  • 2[2]Berthiaume J, Wallace KB. Perfluorooctanoate, perflourooctanesulfonate, and N-ethyl perfluorooctanesulfonamido ethanol; peroxisome proliferation and mitochondrial biogenesis. Toxicol Lett, 2002,129(1-2):23-32
  • 3[3]Sohlenius AK, Eriksson AM, Hogstrom C, et al. Perfluorooctane sulfonic acid is a potent inducer of peroxisomal fatty acid beta-oxidation and other activities known to be affected by peroxisome proliferators in mouse liver . Pharmacol Toxicol, 1993,72(2) :90-93
  • 4[4]Case MT, York RG, Christian MS. Rat and rabbit oral developmental toxicology studies with two perfluorinated compounds. Int J Toxicol 2001, 20(2) :101-109
  • 5[5]Olsen GW, Burris JM, Mandel JH, et al. Serum perfluorooctan sulfonate and hepatic and lipid clinical chemistry tests in fluorochemica production employees. Occup Environ Med, 1999, 41(9):799-806
  • 6[6]Hansen KJ, Clemen LA, Ellefson ME, et al. Compound-specific quantitative characterization of organic fluorochemicals in biologica matrices. Environ Sci Technol, 2001, 35:766-770
  • 7[7]Giesy JP, Kannan K. Global distribution of perfluorooctane sulfonate in wildlife. Environ Sci Technol, 2001, 35:1339-1342
  • 8[8]Kannan K, Franson JC, Bowerman WW, et al. Perfluorooctane sulfonate in fish-eating water birds including bald eagles and albatrosses.Environ Sci Technol, 2001, 35: 3065-3070
  • 9[9]Kannan K, Koistinen J, Beckmen K, et al. Accumulation of perfluorooctane sulfonate in marine mammals. Environ Sci Technol, 2001, 35:1593-1598
  • 10[10]Kannan K, Hansen J, Wade TL, et al. Perfluorooctane sulfonate in Oyster, Crassostrea virginica, from the Gulf of Mexico and the Chesapeake Bay, USA. Arch Environ Contam Toxicol, 2002, 42: 313-318

共引文献66

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职业与健康
2006年 第16期

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